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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Knutson, Sarah K. ; Warholic, Natalie M. ; Wigle, Tim J. ; Klaus, Christine R. ; Allain, Christina J. ; Raimondi, Alejandra ; Scott, Margaret Porter ; Chesworth, Richard ; Moyer, Mikel P. ; Copeland, Robert A. ; Richon, Victoria M. ; Pollock, Roy M. ; Kuntz, Kevin W. ; Keilhack, Heike

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (19), p.7922-7927 [Periódico revisado por pares]

United States: National Academy of Sciences

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2
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma

Knutson, Sarah K ; Kawano, Satoshi ; Minoshima, Yukinori ; Warholic, Natalie M ; Huang, Kuan-Chun ; Xiao, Yonghong ; Kadowaki, Tadashi ; Uesugi, Mai ; Kuznetsov, Galina ; Kumar, Namita ; Wigle, Tim J ; Klaus, Christine R ; Allain, Christina J ; Raimondi, Alejandra ; Waters, Nigel J ; Smith, Jesse J ; Porter-Scott, Margaret ; Chesworth, Richard ; Moyer, Mikel P ; Copeland, Robert A ; Richon, Victoria M ; Uenaka, Toshimitsu ; Pollock, Roy M ; Kuntz, Kevin W ; Yokoi, Akira ; Keilhack, Heike

Molecular cancer therapeutics, 2014-04, Vol.13 (4), p.842-854 [Periódico revisado por pares]

United States

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3
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
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Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas

Knutson, Sarah K ; Warholic, Natalie M ; Johnston, L Danielle ; Klaus, Christine R ; Wigle, Tim J ; Iwanowicz, Dorothy ; Littlefield, Bruce A ; Porter-Scott, Margaret ; Smith, Jesse J ; Moyer, Mikel P ; Copeland, Robert A ; Pollock, Roy M ; Kuntz, Kevin W ; Raimondi, Alejandra ; Keilhack, Heike Tuckermann, Jan Peter

PloS one, 2014-12, Vol.9 (12), p.e111840 [Periódico revisado por pares]

United States: Public Library of Science

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4
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Knutson, Sarah K ; Wigle, Tim J ; Warholic, Natalie M ; Sneeringer, Christopher J ; Allain, Christina J ; Klaus, Christine R ; Sacks, Joelle D ; Raimondi, Alejandra ; Majer, Christina R ; Song, Jeffrey ; Scott, Margaret Porter ; Jin, Lei ; Smith, Jesse J ; Olhava, Edward J ; Chesworth, Richard ; Moyer, Mikel P ; Richon, Victoria M ; Copeland, Robert A ; Keilhack, Heike ; Pollock, Roy M ; Kuntz, Kevin W

Nature chemical biology, 2012-11, Vol.8 (11), p.890-896 [Periódico revisado por pares]

United States: Nature Publishing Group

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5
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
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A687V EZH2 is a gain-of-function mutation found in lymphoma patients

Majer, Christina R. ; Jin, Lei ; Scott, Margaret Porter ; Knutson, Sarah K. ; Kuntz, Kevin W. ; Keilhack, Heike ; Smith, Jesse J. ; Moyer, Mikel P. ; Richon, Victoria M. ; Copeland, Robert A. ; Wigle, Tim J.

FEBS letters, 2012-09, Vol.586 (19), p.3448-3451 [Periódico revisado por pares]

England: Elsevier B.V

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6
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Chan-Penebre, Elayne ; Kuplast, Kristy G ; Majer, Christina R ; Boriack-Sjodin, P Ann ; Wigle, Tim J ; Johnston, L Danielle ; Rioux, Nathalie ; Munchhof, Michael J ; Jin, Lei ; Jacques, Suzanne L ; West, Kip A ; Lingaraj, Trupti ; Stickland, Kimberly ; Ribich, Scott A ; Raimondi, Alejandra ; Scott, Margaret Porter ; Waters, Nigel J ; Pollock, Roy M ; Smith, Jesse J ; Barbash, Olena ; Pappalardi, Melissa ; Ho, Thau F ; Nurse, Kelvin ; Oza, Khyati P ; Gallagher, Kathleen T ; Kruger, Ryan ; Moyer, Mikel P ; Copeland, Robert A ; Chesworth, Richard ; Duncan, Kenneth W

Nature chemical biology, 2015-06, Vol.11 (6), p.432-437 [Periódico revisado por pares]

United States: Nature Publishing Group

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7
Measuring the effectiveness of conservation: a novel framework to quantify the benefits of sage-grouse conservation policy and easements in Wyoming
Measuring the effectiveness of conservation: a novel framework to quantify the benefits of sage-grouse conservation policy and easements in Wyoming
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Measuring the effectiveness of conservation: a novel framework to quantify the benefits of sage-grouse conservation policy and easements in Wyoming

Copeland, Holly E ; Pocewicz, Amy ; Naugle, David E ; Griffiths, Tim ; Keinath, Doug ; Evans, Jeffrey ; Platt, James Boyce, Mark S.

PloS one, 2013-06, Vol.8 (6), p.e67261-e67261 [Periódico revisado por pares]

United States: Public Library of Science

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8
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
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The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states

Wigle, Tim J. ; Knutson, Sarah K. ; Jin, Lei ; Kuntz, Kevin W. ; Pollock, Roy M. ; Richon, Victoria M. ; Copeland, Robert A. ; Scott, Margaret Porter

FEBS letters, 2011-10, Vol.585 (19), p.3011-3014 [Periódico revisado por pares]

England: Elsevier B.V

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9
Drugging the human methylome: an emerging modality for reversible control of aberrant gene transcription
Drugging the human methylome: an emerging modality for reversible control of aberrant gene transcription
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Drugging the human methylome: an emerging modality for reversible control of aberrant gene transcription

Wigle, Tim J ; Copeland, Robert A

Current opinion in chemical biology, 2013-06, Vol.17 (3), p.369-378 [Periódico revisado por pares]

England: Elsevier Ltd

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10
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
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Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound

Mitchell, Lorna H. ; Drew, Allison E. ; Ribich, Scott A. ; Rioux, Nathalie ; Swinger, Kerren K. ; Jacques, Suzanne L. ; Lingaraj, Trupti ; Boriack-Sjodin, P. Ann ; Waters, Nigel J. ; Wigle, Tim J. ; Moradei, Oscar ; Jin, Lei ; Riera, Tom ; Porter-Scott, Margaret ; Moyer, Mikel P. ; Smith, Jesse J. ; Chesworth, Richard ; Copeland, Robert A.

ACS medicinal chemistry letters, 2015-06, Vol.6 (6), p.655-659 [Periódico revisado por pares]

United States: American Chemical Society

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