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Refinado por: data de publicação: 2011Até2015 remover assunto: Methylation remover
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A687V EZH2 is a gain-of-function mutation found in lymphoma patients
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
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A687V EZH2 is a gain-of-function mutation found in lymphoma patients

Majer, Christina R. ; Jin, Lei ; Scott, Margaret Porter ; Knutson, Sarah K. ; Kuntz, Kevin W. ; Keilhack, Heike ; Smith, Jesse J. ; Moyer, Mikel P. ; Richon, Victoria M. ; Copeland, Robert A. ; Wigle, Tim J.

FEBS letters, 2012-09, Vol.586 (19), p.3448-3451 [Periódico revisado por pares]

England: Elsevier B.V

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2
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Chan-Penebre, Elayne ; Kuplast, Kristy G ; Majer, Christina R ; Boriack-Sjodin, P Ann ; Wigle, Tim J ; Johnston, L Danielle ; Rioux, Nathalie ; Munchhof, Michael J ; Jin, Lei ; Jacques, Suzanne L ; West, Kip A ; Lingaraj, Trupti ; Stickland, Kimberly ; Ribich, Scott A ; Raimondi, Alejandra ; Scott, Margaret Porter ; Waters, Nigel J ; Pollock, Roy M ; Smith, Jesse J ; Barbash, Olena ; Pappalardi, Melissa ; Ho, Thau F ; Nurse, Kelvin ; Oza, Khyati P ; Gallagher, Kathleen T ; Kruger, Ryan ; Moyer, Mikel P ; Copeland, Robert A ; Chesworth, Richard ; Duncan, Kenneth W

Nature chemical biology, 2015-06, Vol.11 (6), p.432-437 [Periódico revisado por pares]

United States: Nature Publishing Group

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3
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
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The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states

Wigle, Tim J. ; Knutson, Sarah K. ; Jin, Lei ; Kuntz, Kevin W. ; Pollock, Roy M. ; Richon, Victoria M. ; Copeland, Robert A. ; Scott, Margaret Porter

FEBS letters, 2011-10, Vol.585 (19), p.3011-3014 [Periódico revisado por pares]

England: Elsevier B.V

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4
Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L
Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L
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Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L

Basavapathruni, Aravind ; Jin, Lei ; Daigle, Scott R. ; Majer, Christina R. A. ; Therkelsen, Carly A. ; Wigle, Tim J. ; Kuntz, Kevin W. ; Chesworth, Richard ; Pollock, Roy M. ; Scott, Margaret P. ; Moyer, Mikel P. ; Richon, Victoria M. ; Copeland, Robert A. ; Olhava, Edward J.

Chemical biology & drug design, 2012-12, Vol.80 (6), p.971-980 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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5
A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening
A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening
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A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening

Wigle, Tim J. ; Swinger, Kerren K. ; Campbell, John E. ; Scholle, Michael D. ; Sherrill, John ; Admirand, Elizabeth A. ; Boriack-Sjodin, P. Ann ; Kuntz, Kevin W. ; Chesworth, Richard ; Moyer, Mikel P. ; Scott, Margaret Porter ; Copeland, Robert A.

Journal of biomolecular screening, 2015-07, Vol.20 (6), p.810-820 [Periódico revisado por pares]

Los Angeles, CA: SAGE Publications

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6
Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET
Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET
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Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET

Swalm, Brooke M ; Hallenbeck, Kenneth K ; Majer, Christina R ; Jin, Lei ; Scott, Margaret Porter ; Moyer, Mikel P ; Copeland, Robert A ; Wigle, Tim J

Biochemical journal, 2013-07, Vol.453 (2), p.241-247 [Periódico revisado por pares]

England

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7
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP
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Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP

Basavapathruni, Aravind ; Gureasko JodiauthorEpizyme, Inc., 400 Technology Square, Cambridge, Massachusetts 02139, United States ; Porter Scott MargaretauthorEpizyme, Inc., 400 Technology Square, Cambridge, Massachusetts 02139, United States ; Hermans WilliamauthorBlue Sky BioServices, Worcester, Massachusetts 01605, United States ; Godbole AdarshauthorAldevron, Madison, Wisconsin 53719, United States ; Leland Peter A.authorAldevron, Madison, Wisconsin 53719, United States ; Boriack-Sjodin P. AnnauthorEpizyme, Inc., 400 Technology Square, Cambridge, Massachusetts 02139, United States ; Wigle Tim J.authorEpizyme, Inc., 400 Technology Square, Cambridge, Massachusetts 02139, United States ; Copeland Robert A.authorEpizyme, Inc., 400 Technology Square, Cambridge, Massachusetts 02139, United States ; Riera Thomas V.authorEpizyme, Inc., 400 Technology Square, Cambridge, Massachusetts 02139, United States

2015

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