Robustness and reproducibility of simple and complex synthetic logic circuit designs using a DBTL loop

Breschine Cummins Justin Vrana; Robert C Moseley; Hamed Eramian; Anastasia Deckard; Pedro Fontanarrosa; Daniel Bryce; Mark Weston; George Zheng; Joshua Nowak; Francis C Motta; Mohammed Eslami; Kara Layne Johnson; Robert P Goldman; Chris J Myers; Tessa Johnson; Matthew W Vaughn; Niall Gaffney; Joshua Urrutia; Shweta Gopaulakrishnan; Vanessa Biggers; Trissha R Higa; Lorraine A Mosqueda; Márcio Fuzeto Gameiro; Tomás Gedeon; Konstantin Mischaikow; Jacob Beal; Bryan Bartley; Tom Mitchell; Tramy T Nguyen; Nicholas Roehner; Steve Haase

Oxford 2023

Localização: ICMC - Inst. Ciên. Mat. Computação    (PROD-3140067 )(Acessar)

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

Sehrawat, Archana ; Gao, Lina ; Wang, Yuliang ; Bankhead, Armand ; McWeeney, Shannon K. ; King, Carly J. ; Schwartzman, Jacob ; Urrutia, Joshua ; Bisson, William H. ; Coleman, Daniel J. ; Joshi, Sunil K. ; Kim, Dae-Hwan ; Sampson, David A. ; Weinmann, Sheila ; Kallakury, Bhaskar V. S. ; Berry, Deborah L. ; Haque, Reina ; Van Den Eeden, Stephen K. ; Sharma, Sunil ; Bearss, Jared ; Beer, Tomasz M. ; Thomas, George V. ; Heiser, Laura M. ; Alumkal, Joshi J.

United States: National Academy of Sciences

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BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program

Kim, Dae-Hwan ; Sun, Duanchen ; Storck, William K ; Welker Leng, Katherine ; Jenkins, Chelsea ; Coleman, Daniel J ; Sampson, David ; Guan, Xiangnan ; Kumaraswamy, Anbarasu ; Rodansky, Eva S ; Urrutia, Joshua A ; Schwartzman, Jacob A ; Zhang, Chao ; Beltran, Himisha ; Labrecque, Mark P ; Morrissey, Colm ; Lucas, Jared M ; Coleman, Ilsa M ; Nelson, Peter S ; Corey, Eva ; Handelman, Samuel K ; Sexton, Jonathan Z ; Aggarwal, Rahul ; Abida, Wassim ; Feng, Felix Y ; Small, Eric J ; Spratt, Daniel E ; Bankhead, 3rd, Armand ; Rao, Arvind ; Gesner, Emily M ; Attwell, Sarah ; Lakhotia, Sanjay ; Campeau, Eric ; Yates, Joel A ; Xia, Zheng ; Alumkal, Joshi J

United States

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Copy Number Loss of 17q22 Is Associated with Enzalutamide Resistance and Poor Prognosis in Metastatic Castration-Resistant Prostate Cancer

Guan, Xiangnan ; Sun, Duanchen ; Lu, Eric ; Urrutia, Joshua A ; Reiter, Robert Evan ; Rettig, Matthew ; Evans, Christopher P ; Lara, Jr, Primo ; Gleave, Martin ; Beer, Tomasz M ; Thomas, George V ; Huang, Jiaoti ; Aggarwal, Rahul R ; Quigley, David A ; Foye, Adam ; Chen, William S ; Youngren, Jack ; Weinstein, Alana S ; Stuart, Joshua M ; Feng, Felix Y ; Small, Eric J ; Xia, Zheng ; Alumkal, Joshi J

United States

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BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

Coleman, Daniel J ; Gao, Lina ; King, Carly J ; Schwartzman, Jacob ; Urrutia, Joshua ; Sehrawat, Archana ; Tayou, Junior ; Balter, Ariel ; Burchard, Julja ; Chiotti, Kami E ; Derrick, Daniel S ; Sun, Duanchen ; Xia, Zheng ; Heiser, Laura M ; Alumkal, Joshi J

England: Nature Publishing Group

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Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4

Coleman, Daniel J. ; Sampson, David A. ; Sehrawat, Archana ; Kumaraswamy, Anbarasu ; Sun, Duanchen ; Wang, Yuzhuo ; Schwartzman, Jacob ; Urrutia, Joshua ; Lee, Ahn R. ; Coleman, Ilsa M. ; Nelson, Peter S. ; Dong, Xuesen ; Morrissey, Colm ; Corey, Eva ; Xia, Zheng ; Yates, Joel A. ; Alumkal, Joshi J.

United States: Elsevier Inc

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Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

Coleman, Daniel J ; Gao, Lina ; Schwartzman, Jacob ; Korkola, James E ; Sampson, David ; Derrick, Daniel S ; Urrutia, Joshua ; Balter, Ariel ; Burchard, Julja ; King, Carly J ; Chiotti, Kami E ; Heiser, Laura M ; Alumkal, Joshi J

England: Nature Publishing Group

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Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance

Alumkal, Joshi J. ; Sun, Duanchen ; Lu, Eric ; Beer, Tomasz M. ; Thomas, George V. ; Latour, Emile ; Aggarwal, Rahul ; Cetnar, Jeremy ; Ryan, Charles J. ; Tabatabaei, Shaadi ; Bailey, Shawna ; Turina, Claire B. ; Quigley, David A. ; Guan, Xiangnan ; Foye, Adam ; Youngren, Jack F. ; Urrutia, Joshua ; Huang, Jiaoti ; Weinstein, Alana S. ; Friedl, Verena ; Rettig, Matthew ; Reiter, Robert E. ; Spratt, Daniel E. ; Gleave, Martin ; Evans, Christopher P. ; Stuart, Joshua M. ; Chen, Yiyi ; Feng, Felix Y. ; Small, Eric J. ; Witte, Owen N. ; Xia, Zheng

United States: National Academy of Sciences

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Prediction of whole-cell transcriptional response with machine learning

Eslami, Mohammed ; Borujeni, Amin Espah ; Eramian, Hamed ; Weston, Mark ; Zheng, George ; Urrutia, Joshua ; Corbet, Carolyn ; Becker, Diveena ; Maschhoff, Paul ; Clowers, Katie ; Cristofaro, Alexander ; Hosseini, Hamid Doost ; Gordon, D Benjamin ; Dorfan, Yuval ; Singer, Jedediah ; Vaughn, Matthew ; Gaffney, Niall ; Fonner, John ; Stubbs, Joe ; Voigt, Christopher A ; Yeung, Enoch Birol, Inanc

England: Oxford University Press

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Copy number analysis to identify tumor suppressor genes associated with enzalutamide (Enza) resistance and poor prognosis in metastatic castration-resistant prostate cancer (mCRPC) patients

Guan, Xiangnan ; Sun, Duan-Chen ; Lu, Eric ; Urrutia, Joshua A. ; Reiter, Robert Evan ; Rettig, Matthew ; Evans, Christopher P. ; Lara, Primo ; Gleave, Martin ; Beer, Tomasz M. ; Thomas, George V. ; Huang, Jiaoti ; Xia, Zheng ; Alumkal, Joshi J.

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