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Material Type: Artigo
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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposingRiva, Laura ; Yuan, Shuofeng ; Yin, Xin ; Martin-Sancho, Laura ; Matsunaga, Naoko ; Pache, Lars ; Burgstaller-Muehlbacher, Sebastian ; De Jesus, Paul D ; Teriete, Peter ; Hull, Mitchell V ; Chang, Max W ; Chan, Jasper Fuk-Woo ; Cao, Jianli ; Poon, Vincent Kwok-Man ; Herbert, Kristina M ; Cheng, Kuoyuan ; Nguyen, Tu-Trinh H ; Rubanov, Andrey ; Pu, Yuan ; Nguyen, Courtney ; Choi, Angela ; Rathnasinghe, Raveen ; Schotsaert, Michael ; Miorin, Lisa ; Dejosez, Marion ; Zwaka, Thomas P ; Sit, Ko-Yung ; Martinez-Sobrido, Luis ; Liu, Wen-Chun ; White, Kris M ; Chapman, Mackenzie E ; Lendy, Emma K ; Glynne, Richard J ; Albrecht, Randy ; Ruppin, Eytan ; Mesecar, Andrew D ; Johnson, Jeffrey R ; Benner, Christopher ; Sun, Ren ; Schultz, Peter G ; Su, Andrew I ; García-Sastre, Adolfo ; Chatterjee, Arnab K ; Yuen, Kwok-Yung ; Chanda, Sumit KNature (London), 2020-10, Vol.586 (7827), p.113-119 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safetyBreining, Peter ; Frølund, Anne Lier ; Højen, Jesper Falkesgaard ; Gunst, Jesper Damsgaard ; Staerke, Nina B. ; Saedder, Eva ; Cases‐Thomas, Manuel ; Little, Paul ; Nielsen, Lars Peter ; Søgaard, Ole S. ; Kjolby, MadsBasic & clinical pharmacology & toxicology, 2021-02, Vol.128 (2), p.204-212 [Periódico revisado por pares]England: Wiley Subscription Services, IncTexto completo disponível |
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Material Type: Artigo
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A proteomic atlas of senescence-associated secretomes for aging biomarker developmentBasisty, Nathan ; Kale, Abhijit ; Jeon, Ok Hee ; Kuehnemann, Chisaka ; Payne, Therese ; Rao, Chirag ; Holtz, Anja ; Shah, Samah ; Sharma, Vagisha ; Ferrucci, Luigi ; Campisi, Judith ; Schilling, Birgit Serrano, ManuelPLoS biology, 2020-01, Vol.18 (1), p.e3000599-e3000599 [Periódico revisado por pares]United States: Public Library of ScienceTexto completo disponível |
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Material Type: Artigo
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Biased signalling and proteinase‐activated receptors (PARs): targeting inflammatory diseaseHollenberg, M D ; Mihara, K ; Polley, D ; Suen, J Y ; Han, A ; Fairlie, D P ; Ramachandran, RBritish journal of pharmacology, 2014-03, Vol.171 (5), p.1180-1194 [Periódico revisado por pares]England: Blackwell Publishing LtdTexto completo disponível |
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Material Type: Artigo
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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeuticShapira, Tirosh ; Monreal, I Abrrey ; Dion, Sébastien P ; Buchholz, David W ; Imbiakha, Brian ; Olmstead, Andrea D ; Jager, Mason ; Désilets, Antoine ; Gao, Guang ; Martins, Mathias ; Vandal, Thierry ; Thompson, Connor A H ; Chin, Aaleigha ; Rees, William D ; Steiner, Theodore ; Nabi, Ivan Robert ; Marsault, Eric ; Sahler, Julie ; Diel, Diego G ; Van de Walle, Gerlinde R ; August, Avery ; Whittaker, Gary R ; Boudreault, Pierre-Luc ; Leduc, Richard ; Aguilar, Hector C ; Jean, FrançoisNature (London), 2022-05, Vol.605 (7909), p.340-348 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Human proteinase 3 resistance to inhibition extends to alpha‐2 macroglobulinN’Guessan, Koffi ; Grzywa, Renata ; Seren, Seda ; Gabant, Guillaume ; Juliano, Maria A. ; Moniatte, Marc ; Dorsselaer, Alain ; Bieth, Joseph G. ; Kellenberger, Christine ; Gauthier, Francis ; Wysocka, Magdalena ; Lesner, Adam ; Sienczyk, Marcin ; Cadene, Martine ; Korkmaz, BriceThe FEBS journal, 2020-09, Vol.287 (18), p.4068-4081 [Periódico revisado por pares]England: Blackwell Publishing LtdTexto completo disponível |
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Material Type: Artigo
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Novel scabies mite serpins inhibit the three pathways of the human complement systemMika, Angela ; Reynolds, Simone L ; Mohlin, Frida C ; Willis, Charlene ; Swe, Pearl M ; Pickering, Darren A ; Halilovic, Vanja ; Wijeyewickrema, Lakshmi C ; Pike, Robert N ; Blom, Anna M ; Kemp, David J ; Fischer, Katja Benarafa, CharafPloS one, 2012-07, Vol.7 (7), p.e40489-e40489 [Periódico revisado por pares]United States: Public Library of ScienceTexto completo disponível |
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Material Type: Artigo
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Identification of highly selective covalent inhibitors by phage displayChen, Shiyu ; Lovell, Scott ; Lee, Sumin ; Fellner, Matthias ; Mace, Peter D ; Bogyo, MatthewNature biotechnology, 2021-04, Vol.39 (4), p.490-498 [Periódico revisado por pares]United States: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpinsDe Marco Verissimo, Carolina ; Jewhurst, Heather L ; Dobó, József ; Gál, Péter ; Dalton, John P ; Cwiklinski, Krystyna Skelly, Patrick J.PLoS pathogens, 2022-01, Vol.18 (1), p.e1010226-e1010226 [Periódico revisado por pares]United States: Public Library of ScienceTexto completo disponível |
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Material Type: Artigo
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Retraction: Human Epididymis Protein-4 : A Novel Cross-Class Protease InhibitorPloS one, 2024-06, Vol.19 (6), p.e0305589 [Periódico revisado por pares]San Francisco: Public Library of ScienceTexto completo disponível |