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Material Type: Artigo
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A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteriaTiago Leão Mingxun Wang; Nathan Moss; Ricardo Roberto da Silva; Jon Sanders; Sergey Nurk; Alexey Gurevich; Gregory Humphrey; Raphael Reher; Qiyun Zhu; Pedro Belda-FerreMarine Drugs Basel v. 19, n. 1, art. 20, p. 1-16, 2021Basel 2021Localização: FCFRP - Fac. Ciên. Farm. Ribeirão Preto (pcd 3075157 Acervo Digital )(Acessar) |
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Material Type: Artigo
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A community resource for paired genomic and metabolomic data miningMichelle A. Schorn Stefan Verhoeven; Lars Ridder; Florian Huber; Deepa D. A Acharya; Alexander A Aksenov; Gajender Aleti; Jamshid Amiri Moghaddam; Allegra T Aron; Saefuddin Aziz; Anelize Bauermeister; Katherine D Bauman; Martin Baunach; Christine Beemelmanns; J. Michael Beman; María Victoria Berlanga Clavero; Alex A Blacutt; Helge B Bode; Anne Boullie; Asker Brejnrod; Tim S Bugni; Alexandra Calteau; Liu Cao; Víctor J Carrión; Raquel Castelo Branco; Shaurya Chanana; Alexander B Chase; Marc G Chevrette; Leticia Veras Costa Lotufo; Jason M Crawford; Cameron R Currie; Bart Cuypers; Tam Dang; Tristan de Rond; Alyssa M Demko; Elke Dittmann; Chao Du; Christopher Drozd; Jean-Claude Dujardin; Rachel J Dutton; Ann Edlund; David P Fewer; Neha Garg; Julia M Gauglitz; Emily C Gentry; Lena Gerwick; Evgenia Glukhov; Harald Gross; Muriel Gugger; Dulce G. Guillén Matus; Eric J. N Helfrich; Benjamin-Florian Hempel; Jae-Seoun Hur; Marianna Iorio; Paul R Jensen; Kyo Bin Kang; Leonard Kaysser; Neil L Kelleher; Chung Sub Kim; Ki Hyun Kim; Irina Koester; Gabriele M König; Tiago Leao; Seoung Rak Lee; Yi-Yuan Lee; Xuanji Li; Jessica C Little Maloney,Katherine N.; Daniel Männle; Christian Martin H.; Andrew C McAvoy; Willam W Metcalf; Hosein Mohimani; Carlos Molina Santiago; Bradley S Moore; Michael W Mullowney; Mitchell Muskat; Louis Félix Nothias; Ellis C O’Neill; Elizabeth I Parkinson; Daniel Petras; Jörn Piel; Emily C Pierce; Karine Pires; Raphael Reher; Diego Romero; M. Caroline Roper; Michael Rust; Hamada Saad; Carmen Saenz; Laura M Sanchez; Søren Johann Sørensen; Margherita Sosio; Roderich D Süssmuth; Douglas Sweeney; Kapil Tahlan; Regan J Thomson; Nicholas J Tobias; Amaro Emiliano Trindade Silva; Gilles P. van Wezel; Mingxun Wang; Kelly C Weldon; Fan Zhang; Nadine Ziemert; Katherine R Duncan; Max Crüsemann; Simon Rogers; Pieter C Dorrestein; Marnix H Medema; Justin J. J. van der HooftNature Chemical Biology London 8 p., 2021London 2021Item não circula. Consulte sua biblioteca.(Acessar) |
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Material Type: Artigo
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Systematic classification of unknown metabolites using high-resolution fragmentation mass spectraDührkop, Kai ; Nothias, Louis-Félix ; Fleischauer, Markus ; Reher, Raphael ; Ludwig, Marcus ; Hoffmann, Martin A ; Petras, Daniel ; Gerwick, William H ; Rousu, Juho ; Dorrestein, Pieter C ; Böcker, SebastianNature biotechnology, 2021-04, Vol.39 (4), p.462-471 [Periódico revisado por pares]United States: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Lack of beta-arrestin signaling in the absence of active G proteinsGrundmann, Manuel ; Merten, Nicole ; Malfacini, Davide ; Inoue, Asuka ; Preis, Philip ; Simon, Katharina ; Rüttiger, Nelly ; Ziegler, Nicole ; Benkel, Tobias ; Schmitt, Nina Katharina ; Ishida, Satoru ; Müller, Ines ; Reher, Raphael ; Kawakami, Kouki ; Inoue, Ayumi ; Rick, Ulrike ; Kühl, Toni ; Imhof, Diana ; Aoki, Junken ; König, Gabriele M ; Hoffmann, Carsten ; Gomeza, Jesus ; Wess, Jürgen ; Kostenis, EviNature communications, 2018-01, Vol.9 (1), p.341-16, Article 341 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural ProductsKim, Hyun Woo ; Wang, Mingxun ; Leber, Christopher A. ; Nothias, Louis-Félix ; Reher, Raphael ; Kang, Kyo Bin ; van der Hooft, Justin J. J. ; Dorrestein, Pieter C. ; Gerwick, William H. ; Cottrell, Garrison W.Journal of natural products (Washington, D.C.), 2021-11, Vol.84 (11), p.2795-2807 [Periódico revisado por pares]United States: American Chemical Society and American Society of PharmacognosyTexto completo disponível |
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Material Type: Artigo
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A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural ProductsReher, Raphael ; Kim, Hyun Woo ; Zhang, Chen ; Mao, Huanru Henry ; Wang, Mingxun ; Nothias, Louis-Félix ; Caraballo-Rodriguez, Andres Mauricio ; Glukhov, Evgenia ; Teke, Bahar ; Leao, Tiago ; Alexander, Kelsey L ; Duggan, Brendan M ; Van Everbroeck, Ezra L ; Dorrestein, Pieter C ; Cottrell, Garrison W ; Gerwick, William HJournal of the American Chemical Society, 2020-03, Vol.142 (9), p.4114-4120 [Periódico revisado por pares]United States: American Chemical SocietyTexto completo disponível |
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Material Type: Artigo
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Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi CruzainBoudreau, Paul D ; Miller, Bailey W ; McCall, Laura-Isobel ; Almaliti, Jehad ; Reher, Raphael ; Hirata, Ken ; Le, Thu ; Siqueira-Neto, Jair L ; Hook, Vivian ; Gerwick, William HJournal of medicinal chemistry, 2019-10, Vol.62 (20), p.9026-9044 [Periódico revisado por pares]United States: American Chemical SocietyTexto completo disponível |
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Material Type: Artigo
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Native metabolomics identifies the rivulariapeptolide family of protease inhibitorsReher, Raphael ; Aron, Allegra T. ; Fajtová, Pavla ; Stincone, Paolo ; Wagner, Berenike ; Pérez-Lorente, Alicia I. ; Liu, Chenxi ; Shalom, Ido Y. Ben ; Bittremieux, Wout ; Wang, Mingxun ; Jeong, Kyowon ; Matos-Hernandez, Marie L. ; Alexander, Kelsey L. ; Caro-Diaz, Eduardo J. ; Naman, C. Benjamin ; Scanlan, J. H. William ; Hochban, Phil M. M. ; Diederich, Wibke E. ; Molina-Santiago, Carlos ; Romero, Diego ; Selim, Khaled A. ; Sass, Peter ; Brötz-Oesterhelt, Heike ; Hughes, Chambers C. ; Dorrestein, Pieter C. ; O’Donoghue, Anthony J. ; Gerwick, William H. ; Petras, DanielNature communications, 2022-08, Vol.13 (1), p.4619-4619, Article 4619 [Periódico revisado por pares]London: Nature Publishing GroupTexto completo disponível |
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Material Type: Artigo
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Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq‐Signaling Inhibitor FR900359Crüsemann, Max ; Reher, Raphael ; Schamari, Isabella ; Brachmann, Alexander O. ; Ohbayashi, Tsubasa ; Kuschak, Markus ; Malfacini, Davide ; Seidinger, Alexander ; Pinto‐Carbó, Marta ; Richarz, René ; Reuter, Tatjana ; Kehraus, Stefan ; Hallab, Asis ; Attwood, Misty ; Schiöth, Helgi B. ; Mergaert, Peter ; Kikuchi, Yoshitomo ; Schäberle, Till F. ; Kostenis, Evi ; Wenzel, Daniela ; Müller, Christa E. ; Piel, Jörn ; Carlier, Aurélien ; Eberl, Leo ; König, Gabriele M.Angewandte Chemie (International ed.), 2018-01, Vol.57 (3), p.836-840 [Periódico revisado por pares]Germany: Wiley Subscription Services, IncTexto completo disponível |
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Material Type: Artigo
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Cell‐permeable high‐affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitorsKuschak, Markus ; Namasivayam, Vigneshwaran ; Rafehi, Muhammad ; Voss, Jan H. ; Garg, Jaspal ; Schlegel, Jonathan G. ; Abdelrahman, Aliaa ; Kehraus, Stefan ; Reher, Raphael ; Küppers, Jim ; Sylvester, Katharina ; Hinz, Sonja ; Matthey, Michaela ; Wenzel, Daniela ; Fleischmann, Bernd K. ; Pfeifer, Alexander ; Inoue, Asuka ; Gütschow, Michael ; König, Gabriele M. ; Müller, Christa E.British journal of pharmacology, 2020-04, Vol.177 (8), p.1898-1916 [Periódico revisado por pares]London: Blackwell Publishing LtdTexto completo disponível |