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MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
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MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

Bernt, Kathrin M. ; Zhu, Nan ; Sinha, Amit U. ; Vempati, Sridhar ; Faber, Joerg ; Krivtsov, Andrei V. ; Feng, Zhaohui ; Punt, Natalie ; Daigle, Amanda ; Bullinger, Lars ; Pollock, Roy M. ; Richon, Victoria M. ; Kung, Andrew L. ; Armstrong, Scott A.

Cancer cell, 2011-07, Vol.20 (1), p.66-78 [Periódico revisado por pares]

United States: Elsevier Inc

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2
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Knutson, Sarah K. ; Warholic, Natalie M. ; Wigle, Tim J. ; Klaus, Christine R. ; Allain, Christina J. ; Raimondi, Alejandra ; Scott, Margaret Porter ; Chesworth, Richard ; Moyer, Mikel P. ; Copeland, Robert A. ; Richon, Victoria M. ; Pollock, Roy M. ; Kuntz, Kevin W. ; Keilhack, Heike

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (19), p.7922-7927 [Periódico revisado por pares]

United States: National Academy of Sciences

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3
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

Sneeringer, Christopher J. ; Scott, Margaret Porter ; Kuntz, Kevin W. ; Knutson, Sarah K. ; Pollock, Roy M. ; Richon, Victoria M. ; Copeland, Robert A. ; Wells, James A.

Proceedings of the National Academy of Sciences - PNAS, 2010-12, Vol.107 (49), p.20980-20985 [Periódico revisado por pares]

United States: National Academy of Sciences

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4
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma

Knutson, Sarah K ; Kawano, Satoshi ; Minoshima, Yukinori ; Warholic, Natalie M ; Huang, Kuan-Chun ; Xiao, Yonghong ; Kadowaki, Tadashi ; Uesugi, Mai ; Kuznetsov, Galina ; Kumar, Namita ; Wigle, Tim J ; Klaus, Christine R ; Allain, Christina J ; Raimondi, Alejandra ; Waters, Nigel J ; Smith, Jesse J ; Porter-Scott, Margaret ; Chesworth, Richard ; Moyer, Mikel P ; Copeland, Robert A ; Richon, Victoria M ; Uenaka, Toshimitsu ; Pollock, Roy M ; Kuntz, Kevin W ; Yokoi, Akira ; Keilhack, Heike

Molecular cancer therapeutics, 2014-04, Vol.13 (4), p.842-854 [Periódico revisado por pares]

United States

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5
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Knutson, Sarah K ; Wigle, Tim J ; Warholic, Natalie M ; Sneeringer, Christopher J ; Allain, Christina J ; Klaus, Christine R ; Sacks, Joelle D ; Raimondi, Alejandra ; Majer, Christina R ; Song, Jeffrey ; Scott, Margaret Porter ; Jin, Lei ; Smith, Jesse J ; Olhava, Edward J ; Chesworth, Richard ; Moyer, Mikel P ; Richon, Victoria M ; Copeland, Robert A ; Keilhack, Heike ; Pollock, Roy M ; Kuntz, Kevin W

Nature chemical biology, 2012-11, Vol.8 (11), p.890-896 [Periódico revisado por pares]

United States: Nature Publishing Group

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6
Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma
Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma
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Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

Kawano, Satoshi ; Grassian, Alexandra R ; Tsuda, Masumi ; Knutson, Sarah K ; Warholic, Natalie M ; Kuznetsov, Galina ; Xu, Shanqin ; Xiao, Yonghong ; Pollock, Roy M ; Smith, Jesse S ; Kuntz, Kevin K ; Ribich, Scott ; Minoshima, Yukinori ; Matsui, Junji ; Copeland, Robert A ; Tanaka, Shinya ; Keilhack, Heike Rota, Rossella

PloS one, 2016-07, Vol.11 (7), p.e0158888-e0158888 [Periódico revisado por pares]

United States: Public Library of Science

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7
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Daigle, Scott R. ; Olhava, Edward J. ; Therkelsen, Carly A. ; Basavapathruni, Aravind ; Jin, Lei ; Boriack-Sjodin, P. Ann ; Allain, Christina J. ; Klaus, Christine R. ; Raimondi, Alejandra ; Scott, Margaret Porter ; Waters, Nigel J. ; Chesworth, Richard ; Moyer, Mikel P. ; Copeland, Robert A. ; Richon, Victoria M. ; Pollock, Roy M.

Blood, 2013-08, Vol.122 (6), p.1017-1025 [Periódico revisado por pares]

United States: Elsevier Inc

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8
The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia
The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia
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The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

Stein, Eytan M. ; Garcia-Manero, Guillermo ; Rizzieri, David A. ; Tibes, Raoul ; Berdeja, Jesus G. ; Savona, Michael R. ; Jongen-Lavrenic, Mojca ; Altman, Jessica K. ; Thomson, Blythe ; Blakemore, Stephen J. ; Daigle, Scott R. ; Waters, Nigel J. ; Suttle, A. Benjamin ; Clawson, Alicia ; Pollock, Roy ; Krivtsov, Andrei ; Armstrong, Scott A. ; DiMartino, Jorge ; Hedrick, Eric ; Löwenberg, Bob ; Tallman, Martin S.

Blood, 2018-06, Vol.131 (24), p.2661-2669 [Periódico revisado por pares]

United States: Elsevier Inc

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9
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat
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The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

Kuntz, Kevin W ; Campbell, John E ; Keilhack, Heike ; Pollock, Roy M ; Knutson, Sarah K ; Porter-Scott, Margaret ; Richon, Victoria M ; Sneeringer, Chris J ; Wigle, Tim J ; Allain, Christina J ; Majer, Christina R ; Moyer, Mikel P ; Copeland, Robert A ; Chesworth, Richard

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1556-1564 [Periódico revisado por pares]

United States: American Chemical Society

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10
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Chan-Penebre, Elayne ; Kuplast, Kristy G ; Majer, Christina R ; Boriack-Sjodin, P Ann ; Wigle, Tim J ; Johnston, L Danielle ; Rioux, Nathalie ; Munchhof, Michael J ; Jin, Lei ; Jacques, Suzanne L ; West, Kip A ; Lingaraj, Trupti ; Stickland, Kimberly ; Ribich, Scott A ; Raimondi, Alejandra ; Scott, Margaret Porter ; Waters, Nigel J ; Pollock, Roy M ; Smith, Jesse J ; Barbash, Olena ; Pappalardi, Melissa ; Ho, Thau F ; Nurse, Kelvin ; Oza, Khyati P ; Gallagher, Kathleen T ; Kruger, Ryan ; Moyer, Mikel P ; Copeland, Robert A ; Chesworth, Richard ; Duncan, Kenneth W

Nature chemical biology, 2015-06, Vol.11 (6), p.432-437 [Periódico revisado por pares]

United States: Nature Publishing Group

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