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A Possible Way to Relate the Effects of SARS-CoV-2-Induced Changes in Transferrin to Severe COVID-19-Associated Diseases

Telek, Elek ; Ujfalusi, Zoltán ; Kemenesi, Gábor ; Zana, Brigitta ; Jakab, Ferenc ; Hild, Gabriella ; Lukács, András ; Hild, Gábor

International journal of molecular sciences, 2022-05, Vol.23 (11), p.6189 [Revista revisada por pares]

Switzerland: MDPI AG

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A Possible Way to Relate the Effects of SARS-CoV-2-Induced Changes in Transferrin to Severe COVID-19-Associated Diseases
Autor: Telek, Elek ; Ujfalusi, Zoltán ; Kemenesi, Gábor ; Zana, Brigitta ; Jakab, Ferenc ; Hild, Gabriella ; Lukács, András ; Hild, Gábor
Materias: Body temperature ; calorimetry ; Coronaviruses ; COVID-19 ; COVID-19 vaccines ; Denaturation ; Differential scanning calorimetry ; Disease ; Enthalpy ; Erythropoiesis ; Hemoglobin ; human whole blood ; Infections ; Iron ; Liver cancer ; Melt temperature ; Metabolism ; Pandemics ; Proteins ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Toxicity ; Transferrin ; Viral diseases
Es parte de: International journal of molecular sciences, 2022-05, Vol.23 (11), p.6189
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
The authors contributed equally to this work.
Descripción: SARS-CoV-2 infections are responsible for the COVID-19 pandemic. Transferrin has been found to explain the link between diseases associated with impaired iron transport and COVID-19 infection. The effect of SARS-CoV-2 on human whole blood was studied by differential scanning calorimetry. The analysis of the thermal transition curves showed that the melting temperature of the transferrin-related peak decreased in the presence of SARS-CoV-2. The ratio of the under-curve area of the two main peaks was greatly affected, while the total enthalpy of the heat denaturation remained nearly unchanged in the presence of the virus. These results indicate that SARS-CoV-2, through binding to transferrin, may influence its Fe uptake by inducing thermodynamic changes. Therefore, transferrin may remain in an iron-free apo-conformational state, which depends on the SARS-CoV-2 concentration. SARS-CoV-2 can induce disturbance in erythropoiesis due to toxicity generated by free iron overload.
Editor: Switzerland: MDPI AG
Idioma: Inglés

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A Possible Way to Relate the Effects of SARS-CoV-2-Induced Changes in Transferrin to Severe COVID-19-Associated Diseases

Telek, Elek ; Ujfalusi, Zoltán ; Kemenesi, Gábor ; Zana, Brigitta ; Jakab, Ferenc ; Hild, Gabriella ; Lukács, András ; Hild, Gábor

Switzerland: MDPI AG

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