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Coalescent theory an introduction

John Wakeley

Greenwood Village, Colo Roberts & Co. Publishers c2009

Localização: IB - Instituto de Biociências    (QH430 W149c ) e outros locais(Acessar)

  • Título:
    Coalescent theory an introduction
  • Autor: John Wakeley
  • Assuntos: Genetics, Population -- statistics & numerical data; Models, Genetic; Models, Theoretical; Sequence Analysis, DNA -- statistics & numerical data; Genetics -- Mathematical models; GENÉTICA (METODOLOGIA)
  • Notas: Includes bibliographical references (p. 293-316) and indexes.
  • Descrição: Preface -- 1. Gene genealogies -- 1.1 Genealogies and Genealogical thinking -- 1.2 Mutation and Mutation Models -- 1.3 Measures of DNA sequence polymorphism -- 1.4 Variation at the PDHA1 locus in humans -- 2. Probability theory -- 2.1 Fundamentals of probability theory -- 2.1.1 Events, probabilities, and random variables -- 2.1.2 Four famous probability distributions -- 2.2 Poisson processes -- 2.2.1 Poison process results for the coalescent -- 2.2.2 Convolutions of exponential distributions -- 3. The coalescent -- 3.1 Population genetic models -- 3.1.1 The Wright Fisher model -- 3.1.2 The Moran model -- 3.2 The standard coalescent model -- 3.2.1 Wright Fisher model derivation -- 3.2.2 Moran model derivation -- 3.2.3 Breeding structure and exchangability -- 3.3 Some properties of coalescent genealogies -- 3.3.1 Two measures of the size of genealogy -- 3.3.2 The branching structure of genealogies -- 3.4 Human Neanderthal couples -- 4. Neutral genetic variation -- 4.1 The infinite sites model and measures of DNA sequence polymorphism -- 4.1.1 The number segregating sites -- 4.1.2 Pairwise differences -- 4.1.3 Site frequencies -- 4.2 The infinite alleles model and the Ewens sampling formula -- 4.3 Deviations from the coalescent : testing neutrality -- 4.3.1 Test statistics based on site frequencies -- 4.3.2 Demographic history and patterns of polymorphism -- 4.4 Footprints of positive selection in Drosophila simulans -- 5. The structured coalescent -- 5.1 Markov processes -- 5.1.1 Classification of states and limiting behavior -- 5.1.2 Continuous time approximations and jump chains -- 5.1.3 First step analysis -- 5.2 The structured coalescent -- 5.2.1 Predictions for samples of size 2 -- 5.3 Geographic structure -- 5.3.1 Subdivision with migration -- 5.3.2 Gene trees versus species trees in Australian grass finches -- 5.4 Strong natural selection -- 5.4.1 Selective sweeps -- 5.4.2 Balancing selection at the Adh Locus in Drosophila melanogaster -- 6. Separa
    "An introduction to coalescent theory, which provides the foundation for molecular population genetics and genomics. Coalescent theory is the conceptual framework for studies of DNA sequence variation within species, and is the source of essential tools for making inferences about mutation, recombination, population structure and natural selection from DNA sequence data"--Provided by publisher
  • Editor: Greenwood Village, Colo Roberts & Co. Publishers
  • Data de criação/publicação: c2009
  • Formato: xii, 326 p ill. 24 cm.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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