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Large-Scale Functionalized Metasurface-Based SARS-CoV‑2 Detection and Quantification

Ahmed, Rajib ; Guimarães, Carlos F. ; Wang, Jie ; Soto, Fernando ; Karim, Asma H. ; Zhang, Zhaowei ; Reis, Rui L. ; Akin, Demir ; Paulmurugan, Ramasamy ; Demirci, Utkan

ACS nano, 2022-10, Vol.16 (10), p.15946-15958 [Periódico revisado por pares]

United States: American Chemical Society

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  • Título:
    Large-Scale Functionalized Metasurface-Based SARS-CoV‑2 Detection and Quantification
  • Autor: Ahmed, Rajib ; Guimarães, Carlos F. ; Wang, Jie ; Soto, Fernando ; Karim, Asma H. ; Zhang, Zhaowei ; Reis, Rui L. ; Akin, Demir ; Paulmurugan, Ramasamy ; Demirci, Utkan
  • Assuntos: Biosensing Techniques ; COVID-19 - diagnosis ; Humans ; Metals ; Proteins - chemistry ; SARS-CoV-2
  • É parte de: ACS nano, 2022-10, Vol.16 (10), p.15946-15958
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    This article is made available via the ACS COVID-19 subset for unrestricted RESEARCH re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
  • Descrição: Plasmonic metasurfaces consist of metal–dielectric interfaces that are excitable at background and leakage resonant modes. The sharp and plasmonic excitation profile of metal-free electrons on metasurfaces at the nanoscale can be used for practical applications in diverse fields, including optoelectronics, energy harvesting, and biosensing. Currently, Fano resonant metasurface fabrication processes for biosensor applications are costly, need clean room access, and involve limited small-scale surface areas that are not easy for accurate sample placement. Here, we leverage the large-scale active area with uniform surface patterns present on optical disc-based metasurfaces as a cost-effective method to excite asymmetric plasmonic modes, enabling tunable optical Fano resonance interfacing with a microfluidic channel for multiple target detection in the visible wavelength range. We engineered plasmonic metasurfaces for biosensing through efficient layer-by-layer surface functionalization toward real-time measurement of target binding at the molecular scale. Further, we demonstrated the quantitative detection of antibodies, proteins, and the whole viral particles of SARS-CoV-2 with a high sensitivity and specificity, even distinguishing it from similar RNA viruses such as influenza and MERS. This cost-effective plasmonic metasurface platform offers a small-scale light-manipulation system, presenting considerable potential for fast, real-time detection of SARS-CoV-2 and pathogens in resource-limited settings.
  • Editor: United States: American Chemical Society
  • Idioma: Inglês
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