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Atypical Enteropathogenic Escherichia coli: from Kittens to Humans and Beyond

Bhatt, Shantanu Brodsky, Igor E ; Brodsky, Igor E.

Infection and immunity, 2021-02, Vol.89 (3) [Periódico revisado por pares]

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Título:
Atypical Enteropathogenic Escherichia coli: from Kittens to Humans and Beyond
Autor: Bhatt, Shantanu
Brodsky, Igor E ; Brodsky, Igor E.
Assuntos: Commentary
É parte de: Infection and immunity, 2021-02, Vol.89 (3)
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
ObjectType-Commentary-1
For the article discussed, see https://doi.org/10.1128/IAI.00619-20.
Citation Bhatt S. 2021. Atypical enteropathogenic Escherichia coli: from kittens to humans and beyond! Infect Immun 89:e00752-20. https://doi.org/10.1128/IAI.00752-20.
Descrição: Atypical enteropathogenic (aEPEC) are associated with diarrhea worldwide, yet genome-wide investigations to probe their virulome are lacking. In this issue of , V. E. Watson, T. H. Hazen, D. A. Rasko, M. E. Jacob, et al. (IAI 89:e00619-20, 2020, https://doi.org/10.1128/IAI.00619-20) sequenced aEPEC isolates from diarrheic and asymptomatic kittens. Using phylogenomics, they demonstrated that these isolates were genetically indistinguishable from human isolates, suggesting that kittens may serve as a reservoir and, perhaps, a much-needed model to interrogate aEPEC virulence. The diarrheic isolates were hypermotile, suggesting that this phenotype may distinguish virulent strains from their innocuous counterparts.
Editor: United States: American Society for Microbiology
Idioma: Inglês

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