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Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests

Nieoczym, Dorota ; Socała, Katarzyna ; Gawel, Kinga ; Esguerra, Camila V. ; Wyska, Elżbieta ; Wlaź, Piotr

Neurochemical research, 2019-05, Vol.44 (5), p.1043-1055 [Periódico revisado por pares]

New York: Springer US

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Título:
Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests
Autor: Nieoczym, Dorota ; Socała, Katarzyna ; Gawel, Kinga ; Esguerra, Camila V. ; Wyska, Elżbieta ; Wlaź, Piotr
Assuntos: Animal models ; Animals ; Anticonvulsants ; Anticonvulsants - therapeutic use ; Antidepressive Agents - pharmacology ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Biology ; Central nervous system ; Convulsions & seizures ; Danio rerio ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Electroshock - adverse effects ; Epilepsy ; Grip strength ; Incubation ; Intravenous administration ; Larvae ; Locomotor activity ; Mice ; Motor ability ; Motors ; Muscle Strength - drug effects ; Neurochemistry ; Neurology ; Neurosciences ; Original Paper ; Pentylenetetrazole ; Pentylenetetrazole - pharmacology ; Resveratrol ; Seizing ; Seizures ; Seizures - chemically induced ; Seizures - drug therapy ; Statistical analysis ; Stilbenes - pharmacology ; Zebrafish
É parte de: Neurochemical research, 2019-05, Vol.44 (5), p.1043-1055
Notas: NFR/187615
Descrição: Pterostilbene (PTE), a natural dimethylated analog of resveratrol, possesses numerous health-beneficial properties. The ability of PTE to cross the blood–brain barrier raised the possibility that this compound may modulate central nervous system functions, including seizure activity. The aim of our study was to investigate the activity of PTE in the larval zebrafish pentylenetetrazole (PTZ) seizure assay and three acute seizure tests in mice, i.e., in the maximal electroshock seizure threshold (MEST), 6 Hz-induced psychomotor seizure threshold and intravenous ( iv ) PTZ tests. Additionally, potential antidepressant activity of PTE was estimated in the forced swim test in mice. The chimney test was used to determine the influence of PTE on motor coordination in mice, while its influence on neuromuscular strength was assessed in the grip strength test in mice. Locomotor activity was determined to verify the results from the forced swim test. PTE revealed an evident anticonvulsant effect both in zebrafish larvae (10 µM; 2 h-incubation) and mice (at doses of 100 and 200 mg/kg, intraperitoneally) but it did not exhibit antidepressant potential in the forced swim test. Furthermore, it did not cause any statistically significant changes in motor coordination, neuromuscular strength and locomotor activity in mice. In conclusion, our present findings demonstrate for the first time the anticonvulsant potential of PTE. The aforementioned results suggest that it might be employed in epilepsy treatment, however, further precise studies are required to verify its activity in other experimental seizure and epilepsy models and its precise mechanism of action should be determined.
Editor: New York: Springer US
Idioma: Inglês;Norueguês

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Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests

Nieoczym, Dorota ; Socała, Katarzyna ; Gawel, Kinga ; Esguerra, Camila V. ; Wyska, Elżbieta ; Wlaź, Piotr

New York: Springer US

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