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Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer

Donovan, Jenny L ; Hamdy, Freddie C ; Lane, J. Athene ; Mason, Malcolm ; Metcalfe, Chris ; Walsh, Eleanor ; Blazeby, Jane M ; Peters, Tim J ; Holding, Peter ; Bonnington, Susan ; Lennon, Teresa ; Bradshaw, Lynne ; Cooper, Deborah ; Herbert, Phillipa ; Howson, Joanne ; Jones, Amanda ; Lyons, Norma ; Salter, Elizabeth ; Thompson, Pauline ; Tidball, Sarah ; Blaikie, Jan ; Gray, Catherine ; Bollina, Prasad ; Catto, James ; Doble, Andrew ; Doherty, Alan ; Gillatt, David ; Kockelbergh, Roger ; Kynaston, Howard ; Paul, Alan ; Powell, Philip ; Prescott, Stephen ; Rosario, Derek J ; Rowe, Edward ; Davis, Michael ; Turner, Emma L ; Martin, Richard M ; Neal, David E

The New England journal of medicine, 2016-10, Vol.375 (15), p.1425-1437 [Peer Reviewed Journal]

United States: Massachusetts Medical Society

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Title:
Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
Author: Donovan, Jenny L ; Hamdy, Freddie C ; Lane, J. Athene ; Mason, Malcolm ; Metcalfe, Chris ; Walsh, Eleanor ; Blazeby, Jane M ; Peters, Tim J ; Holding, Peter ; Bonnington, Susan ; Lennon, Teresa ; Bradshaw, Lynne ; Cooper, Deborah ; Herbert, Phillipa ; Howson, Joanne ; Jones, Amanda ; Lyons, Norma ; Salter, Elizabeth ; Thompson, Pauline ; Tidball, Sarah ; Blaikie, Jan ; Gray, Catherine ; Bollina, Prasad ; Catto, James ; Doble, Andrew ; Doherty, Alan ; Gillatt, David ; Kockelbergh, Roger ; Kynaston, Howard ; Paul, Alan ; Powell, Philip ; Prescott, Stephen ; Rosario, Derek J ; Rowe, Edward ; Davis, Michael ; Turner, Emma L ; Martin, Richard M ; Neal, David E
Subjects: Aged ; Anxiety ; Cancer surgery ; Clinical outcomes ; Clinical trials ; Comparative studies ; Data processing ; Digestive System Diseases ; Erectile Dysfunction ; Health Status ; Humans ; Intention to Treat Analysis ; Intestine ; Male ; Mental depression ; Middle Aged ; Motivation ; Outcome Assessment, Health Care ; Patients ; Prostate cancer ; Prostatectomy ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - radiotherapy ; Prostatic Neoplasms - surgery ; Prostatic Neoplasms - therapy ; Quality of Life ; Radiation therapy ; Surgery ; Surveys and Questionnaires ; Treatment Outcome ; Urologic Diseases ; Urological surgery ; Watchful Waiting
Is Part Of: The New England journal of medicine, 2016-10, Vol.375 (15), p.1425-1437
Notes: ObjectType-Article-2
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The authors’ full names, academic degrees, and affiliations are listed in the Appendix.
A complete list of investigators in the Prostate Testing for Cancer and Treatment (ProtecT) Study Group is provided in the Supplementary Appendix, available at NEJM.org.
Description: The choice of treatment for PSA-detected, localized prostate cancer is influenced by effects of the interventions on quality of life. In the ProtecT trial, patterns of side-effect severity, improvement, and decline in urinary, sexual, and bowel function differed among the treatments. As reported in a companion article in the Journal, the U.K. National Institute for Health Research–supported Prostate Testing for Cancer and Treatment (ProtecT) trial has shown no significant difference in prostate-cancer–specific mortality or all-cause mortality among men with prostate cancer detected by prostate-specific antigen (PSA) testing who were randomly assigned to radical prostatectomy, active monitoring (a surveillance strategy), or radical conformal radiotherapy with neoadjuvant hormonal therapy, at a median of 10 years of follow-up; however, the ProtecT trial has shown higher rates of metastases and disease progression among men in the active-monitoring group than among men in the radical-treatment groups. . . .
Publisher: United States: Massachusetts Medical Society
Language: English

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Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer

United States: Massachusetts Medical Society

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