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Cholinergic control of inflammation

Rosas‐Ballina, M. ; Tracey, K. J.

Journal of internal medicine, 2009-06, Vol.265 (6), p.663-679 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Cholinergic control of inflammation
Autor: Rosas‐Ballina, M. ; Tracey, K. J.
Assuntos: Acetylcholine - immunology ; alpha7 ; Animals ; Biological and medical sciences ; Brain - metabolism ; cholinergic ; Cholinergic Agents - immunology ; General aspects ; inflammation ; Inflammation - immunology ; innate immunity ; Medical sciences ; Mice ; Mice, Knockout ; Neural Pathways - metabolism ; Receptors, Cholinergic - immunology ; Receptors, Cholinergic - metabolism ; Receptors, Nicotinic - metabolism ; Sepsis - immunology ; Tumor Necrosis Factor-alpha - metabolism ; Vagus Nerve - immunology ; Vagus Nerve - physiology
É parte de: Journal of internal medicine, 2009-06, Vol.265 (6), p.663-679
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: . Cytokine production is necessary to protect against pathogens and promote tissue repair, but excessive cytokine release can lead to systemic inflammation, organ failure and death. Inflammatory responses are finely regulated to effectively guard from noxious stimuli. The central nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. The effect of glucocorticoids and other humoral mediators on inflammatory responses has been studied extensively in the past decades. In contrast, neural control of inflammation has only been recently described. We summarize autonomic regulation of local and systemic inflammation through the ‘cholinergic anti‐inflammatory pathway’, a mechanism consisting of the vagus nerve and its major neurotransmitter, acetylcholine, a process dependent on the nicotinic acetylcholine receptor α7 subunit. We recapitulate additional sources of acetylcholine and their contribution to the inflammatory response, as well as acetylcholine regulation by acetylcholinesterase as a means to attenuate inflammation. We discuss potential therapeutic applications to treat diseases characterized by acute or chronic inflammation, including autoimmune diseases, and propose future research directions.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Cholinergic control of inflammation

Rosas‐Ballina, M. ; Tracey, K. J.

Oxford, UK: Blackwell Publishing Ltd

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