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Structural simplification of bioactive natural products with multicomponent synthesis: Dihydropyridopyrazole analogues of podophyllotoxin

Magedov, Igor V. ; Manpadi, Madhuri ; Rozhkova, Elena ; Przheval’skii, Nikolai M. ; Rogelj, Snezna ; Shors, Scott T. ; Steelant, Wim F.A. ; slambrouck, Severine Van ; Kornienko, Alexander

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1381-1385 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Structural simplification of bioactive natural products with multicomponent synthesis: Dihydropyridopyrazole analogues of podophyllotoxin
Autor: Magedov, Igor V. ; Manpadi, Madhuri ; Rozhkova, Elena ; Przheval’skii, Nikolai M. ; Rogelj, Snezna ; Shors, Scott T. ; Steelant, Wim F.A. ; slambrouck, Severine Van ; Kornienko, Alexander
Assuntos: Antimitotic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Apoptosis - drug effects ; Biological Products - chemical synthesis ; Humans ; Jurkat Cells ; Methods ; Multicomponent synthesis ; Podophyllotoxin ; Podophyllotoxin - analogs & derivatives ; Podophyllotoxin - chemical synthesis ; Podophyllotoxin - pharmacology ; Pyrazoles - chemistry ; Structure-Activity Relationship
É parte de: Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1381-1385
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: A three-component condensation of 5-amino-3-methylpyrazole, tetronic acid, and various aromatic, heteroaromatic, and aliphatic aldehydes leads to the formation of dihydropyridopyrazole analogues of a cytotoxic lignan podophyllotoxin. This new heterocyclic scaffold-based library allows a drastic reduction of the structural complexity of the natural product with the retention of its potent cytotoxic properties. Similarly to podophyllotoxin, the presented analogues induce apoptosis in Jurkat cells.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês;Russo

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Structural simplification of bioactive natural products with multicomponent synthesis: Dihydropyridopyrazole analogues of podophyllotoxin

Magedov, Igor V. ; Manpadi, Madhuri ; Rozhkova, Elena ; Przheval’skii, Nikolai M. ; Rogelj, Snezna ; Shors, Scott T. ; Steelant, Wim F.A. ; slambrouck, Severine Van ; Kornienko, Alexander

Oxford: Elsevier Ltd

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