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Immunoglobulin Therapy of Fetal Cytomegalovirus Infection Occurring in the First Half of Pregnancy—A Case-Control Study of the Outcome in Children

Nigro, Giovanni ; Adler, Stuart P. ; Parruti, Giustino ; Anceschi, Maurizio M. ; Coclite, Eleonora ; Pezone, Ilaria ; Di Renzo, Gian Carlo

The Journal of infectious diseases, 2012-01, Vol.205 (2), p.215-227 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Immunoglobulin Therapy of Fetal Cytomegalovirus Infection Occurring in the First Half of Pregnancy—A Case-Control Study of the Outcome in Children
Autor: Nigro, Giovanni ; Adler, Stuart P. ; Parruti, Giustino ; Anceschi, Maurizio M. ; Coclite, Eleonora ; Pezone, Ilaria ; Di Renzo, Gian Carlo
Assuntos: Adult ; Antibodies ; Biological and medical sciences ; Case-Control Studies ; Child, Preschool ; Children ; Cytomegalovirus ; Cytomegalovirus infections ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - drug therapy ; Female ; Fetal Diseases - drug therapy ; Fetal Diseases - virology ; Fetus ; Fundamental and applied biological sciences. Psychology ; Hearing Loss - prevention & control ; Hearing Loss - virology ; Humans ; Immunization, Passive ; Immunoglobulins ; Immunoglobulins - therapeutic use ; Infant ; Infections ; Infectious diseases ; Logistic Models ; Male ; Medical sciences ; Microbiology ; Passive immunization ; Pregnancy ; Pregnancy Complications, Infectious - drug therapy ; Pregnancy Complications, Infectious - virology ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Psychomotor Disorders - prevention & control ; Psychomotor Disorders - virology ; VIRUSES ; Women ; Young Adult
É parte de: The Journal of infectious diseases, 2012-01, Vol.205 (2), p.215-227
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SourceType-Scholarly Journals-1
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Descrição: Background. Primary cytomegalovirus (CMV) infection early in gestation causes severe disease. Methods. Case patients were 32 congenitally infected children aged 1-5 years who had either hearing deficit and/or psychomotor retardation and whose mothers had a confirmed or probable primary CMV infection at ≤20 weeks' gestation. Control subjects were 32 congenitally infected normal children whose mothers had a confirmed primary infection at < 20 weeks' gestation. Case patients and control subjects were matched by the weeks of maternal gestation (±1 week) at the mother's infection and by the child's age (±1 year) at evaluation. Results. For the case patients and control subjects, the mean age was 3.0 years. The mean number of weeks of gestation at maternal infection was 11 weeks. The only risk factor for an affected child was the mother not receiving immunoglobulin (P = .001). Of the 32 case patients, only 4 mothers received CMV immunoglobulin, compared with 27 of the 32 mothers of control infants (adjusted odds ratio, 14 [95% confidence interval, 1.7-110] ). The rate of both psychomotor retardation and hearing deficit decreased with immunoglobulin. Conclusions. These results support the efficacy of immunoglobulins for decreasing the severity of disabilities caused by fetal CMV infection after a primary maternal infection during pregnancy.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Immunoglobulin Therapy of Fetal Cytomegalovirus Infection Occurring in the First Half of Pregnancy—A Case-Control Study of the Outcome in Children

Nigro, Giovanni ; Adler, Stuart P. ; Parruti, Giustino ; Anceschi, Maurizio M. ; Coclite, Eleonora ; Pezone, Ilaria ; Di Renzo, Gian Carlo

Oxford: Oxford University Press

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