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METASTATIC ABILITY AND EXPRESSION OF c-fos ONCOGENE IN CELL CLONES OF A SPONTANEOUS RAT MAMMARY TUMOR

YUHKI, Naoya ; HAMADA, Jun-ichi ; KUZUMAKI, Noboru ; TAKEICHI, Noritoshi ; KOBAYASHI, Hiroshi

Japanese Journal of Cancer Research GANN, 1986, Vol.77(1), pp.9-12

Tokyo: The Japanese Cancer Association

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Título:
METASTATIC ABILITY AND EXPRESSION OF c-fos ONCOGENE IN CELL CLONES OF A SPONTANEOUS RAT MAMMARY TUMOR
Autor: YUHKI, Naoya ; HAMADA, Jun-ichi ; KUZUMAKI, Noboru ; TAKEICHI, Noritoshi ; KOBAYASHI, Hiroshi
Assuntos: Animal tumors. Experimental tumors ; Animals ; Biological and medical sciences ; Cell Line ; Clone Cells ; Experimental genital and mammary tumors ; Female ; fos oncogene ; Mammary Neoplasms, Experimental - genetics ; Mammary Neoplasms, Experimental - pathology ; Mammary tumor ; Medical sciences ; Metastasis ; Neoplasm Metastasis ; Oncogenes ; Rats ; Rats, Inbred SHR ; RNA, Messenger - analysis ; Tumors
É parte de: Japanese Journal of Cancer Research GANN, 1986, Vol.77(1), pp.9-12
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: It was found that cell clones cl-2, cl-2r, cl-3, cl-4 and cl-6 of a spontaneous rat mammary tumor, c-SST-2, exhibit different degrees of metastatic ability: cl-2, cl-3, cl-6 were highly metastatic, while cl-2r and cl-4 were weakly metastatic. The expression of several oncogenes in these clones was examined. The amounts of myc mRNA in the clones were nearly the same. Expression of N-ras mRNA was higher in cl-2r and cl-4 than in cl-2, cl-3 and cl-6. On the other hand, the amounts of fos mRNA in the weakly metastatic clones were markedly lower than those in the highly metastatic clones. These results suggest that fos oncogene plays a role in the high metastatic ability of c-SST-2.
Editor: Tokyo: The Japanese Cancer Association
Idioma: Inglês

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METASTATIC ABILITY AND EXPRESSION OF c-fos ONCOGENE IN CELL CLONES OF A SPONTANEOUS RAT MAMMARY TUMOR

YUHKI, Naoya ; HAMADA, Jun-ichi ; KUZUMAKI, Noboru ; TAKEICHI, Noritoshi ; KOBAYASHI, Hiroshi

Tokyo: The Japanese Cancer Association

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