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Cold Machine Perfusion Versus Static Cold Storage of Kidneys Donated After Cardiac Death: A UK Multicenter Randomized Controlled Trial

Watson, C. J. E. ; Wells, A. C. ; Roberts, R. J. ; Akoh, J. A. ; Friend, P. J. ; Akyol, M. ; Calder, F. R. ; Allen, J. E. ; Jones, M. N. ; Collett, D. ; Bradley, J. A.

American journal of transplantation, 2010-09, Vol.10 (9), p.1991-1999 [Periódico revisado por pares]

Malden, USA: Blackwell Publishing Inc

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Título:
Cold Machine Perfusion Versus Static Cold Storage of Kidneys Donated After Cardiac Death: A UK Multicenter Randomized Controlled Trial
Autor: Watson, C. J. E. ; Wells, A. C. ; Roberts, R. J. ; Akoh, J. A. ; Friend, P. J. ; Akyol, M. ; Calder, F. R. ; Allen, J. E. ; Jones, M. N. ; Collett, D. ; Bradley, J. A.
Assuntos: Acute Disease ; Adult ; Biological and medical sciences ; Cardiac death donors ; Cryopreservation - methods ; Death ; Delayed Graft Function - epidemiology ; Female ; Graft Rejection - epidemiology ; Human viral diseases ; Humans ; Incidence ; Infectious diseases ; Kidney - physiopathology ; kidney preservation ; Kidney Transplantation ; machine preservation ; Male ; Medical sciences ; Middle Aged ; Organ Preservation - instrumentation ; Organ Preservation - methods ; Perfusion - instrumentation ; Postoperative Period ; Pulsatile Flow ; Refrigeration ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Tissue Donors ; Treatment Outcome ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases
É parte de: American journal of transplantation, 2010-09, Vol.10 (9), p.1991-1999
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-News-2
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Descrição: One third of deceased donor kidneys for transplantation in the UK are donated following cardiac death (DCD). Such kidneys have a high rate of delayed graft function (DGF) following transplantation. We conducted a multicenter, randomized controlled trial to determine whether kidney preservation using cold, pulsatile machine perfusion (MP) was superior to simple cold storage (CS) for DCD kidneys. One kidney from each DCD donor was randomly allocated to CS, the other to MP. A sequential trial design was used with the primary endpoint being DGF, defined as the necessity for dialysis within the first 7 days following transplant. The trial was stopped when data were available for 45 pairs of kidneys. There was no difference in the incidence of DGF between kidneys assigned to MP or CS (58% vs. 56%, respectively), in the context of an asystolic period of 15 min and median cold ischemic times of 13.9 h for MP and 14.3 h for CS kidneys. Renal function at 3 and 12 months was similar between groups, as was graft and patient survival. For kidneys from controlled DCD donors (with mean cold ischemic times around 14 h), MP offers no advantage over CS, which is cheaper and more straightforward. Machine perfusion and simple cold storage of DCD kidneys produce equivalent transplant outcome in a UK multicentre randomised controlled trial. See editorial by Irish & Katz on page 1955.
Editor: Malden, USA: Blackwell Publishing Inc
Idioma: Inglês

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Cold Machine Perfusion Versus Static Cold Storage of Kidneys Donated After Cardiac Death: A UK Multicenter Randomized Controlled Trial

Watson, C. J. E. ; Wells, A. C. ; Roberts, R. J. ; Akoh, J. A. ; Friend, P. J. ; Akyol, M. ; Calder, F. R. ; Allen, J. E. ; Jones, M. N. ; Collett, D. ; Bradley, J. A.

Malden, USA: Blackwell Publishing Inc

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