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Neuropeptide Y is neuroproliferative for post‐natal hippocampal precursor cells

Howell, Owain W. ; Scharfman, Helen E. ; Herzog, Herbert ; Sundstrom, Lars E. ; Beck‐Sickinger, Annette ; Gray, William P.

Journal of neurochemistry, 2003-08, Vol.86 (3), p.646-659 [Periódico revisado por pares]

Oxford, UK: Blackwell Science Ltd

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Título:
Neuropeptide Y is neuroproliferative for post‐natal hippocampal precursor cells
Autor: Howell, Owain W. ; Scharfman, Helen E. ; Herzog, Herbert ; Sundstrom, Lars E. ; Beck‐Sickinger, Annette ; Gray, William P.
Assuntos: Animals ; Animals, Newborn ; Antigens, Differentiation - biosynthesis ; Biological and medical sciences ; Bromodeoxyuridine ; cell culture ; Cell cycle, cell proliferation ; Cell Differentiation - drug effects ; Cell Division - drug effects ; Cell physiology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Fibroblast Growth Factor 2 - pharmacology ; Fundamental and applied biological sciences. Psychology ; hippocampus ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - metabolism ; Intermediate Filament Proteins - biosynthesis ; Mice ; Mice, Knockout ; Molecular and cellular biology ; Nerve Tissue Proteins ; Nestin ; neurogenesis ; neuropeptide Y ; Neuropeptide Y - pharmacology ; Rats ; Rats, Wistar ; Receptors, Neuropeptide Y - deficiency ; Receptors, Neuropeptide Y - genetics ; Receptors, Neuropeptide Y - metabolism ; Spheroids, Cellular - cytology ; Spheroids, Cellular - drug effects ; stem cell ; Stem Cells - cytology ; Stem Cells - drug effects ; Stem Cells - metabolism ; transgenic mouse ; Tubulin - biosynthesis
É parte de: Journal of neurochemistry, 2003-08, Vol.86 (3), p.646-659
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Descrição: New neurones are produced in the adult hippocampus throughout life and are necessary for certain types of hippocampal learning. Little, however, is known about the control of hippocampal neurogenesis. We used primary hippocampal cultures from early post‐natal rats and neuropeptide Y Y1 receptor knockout mice as well as selective neuropeptide Y receptor antagonists and agonists to demonstrate that neuropeptide Y is proliferative for nestin‐positive, sphere‐forming hippocampal precursor cells and β‐tubulin‐positive neuroblasts and that the neuroproliferative effect of neuropeptide Y is mediated via its Y1 receptor. Immunohistochemistry confirmed Y1 receptor staining on both nestin‐positive cells and β‐tubulin‐positive cells in culture and short pulse 5‐bromo‐2‐deoxyuridine studies demonstrated that neuropeptide Y has a proliferative effect on both cell types. These studies suggest that the proliferation of hippocampal neuroblasts and precursor cells is increased by neuropeptide Y and, therefore, that hippocampal learning and memory may be modulated by neuropeptide Y‐releasing interneurones.
Editor: Oxford, UK: Blackwell Science Ltd
Idioma: Inglês

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Neuropeptide Y is neuroproliferative for post‐natal hippocampal precursor cells

Howell, Owain W. ; Scharfman, Helen E. ; Herzog, Herbert ; Sundstrom, Lars E. ; Beck‐Sickinger, Annette ; Gray, William P.

Oxford, UK: Blackwell Science Ltd

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