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Genetic Study of Saudi Diabetes (GSSD): significant association of the KCNJ11 E23K polymorphism with type 2 diabetes

Alsmadi, Osama ; Al-Rubeaan, Khalid ; Wakil, Salma M. ; Imtiaz, Faiqa ; Mohamed, Gamal ; Al-Saud, Haya ; Al-Saud, Nouran Abu ; Aldaghri, Nasser ; Mohammad, Shahinaz ; Meyer, Brian F

Diabetes/metabolism research and reviews, 2008-02, Vol.24 (2), p.137-140 [Periódico revisado por pares]

Chichester, UK: John Wiley & Sons, Ltd

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Título:
Genetic Study of Saudi Diabetes (GSSD): significant association of the KCNJ11 E23K polymorphism with type 2 diabetes
Autor: Alsmadi, Osama ; Al-Rubeaan, Khalid ; Wakil, Salma M. ; Imtiaz, Faiqa ; Mohamed, Gamal ; Al-Saud, Haya ; Al-Saud, Nouran Abu ; Aldaghri, Nasser ; Mohammad, Shahinaz ; Meyer, Brian F
Assuntos: Aged ; Aged, 80 and over ; Arabs - genetics ; association ; Biological and medical sciences ; Case-Control Studies ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; E23k polymorphism ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Humans ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Genetic ; Potassium Channels, Inwardly Rectifying - genetics ; Regression Analysis ; Saudi Arabia - epidemiology ; type 2 diabetes ; Vertebrates: endocrinology
É parte de: Diabetes/metabolism research and reviews, 2008-02, Vol.24 (2), p.137-140
Notas: King Faisal Specialist Hospital and Research Centre (KFSH&RC)
King Abdulaziz University Hospital (KAUH)
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Descrição: Background The E23K variant of KCNJ11 has been associated with type 2 diabetes (T2D) in several but not all populations studied. Thus far, despite a high incidence of T2D, the role of this variant in Arabs has not been established. Methods We performed a case‐control association study using 550 T2D Saudi patients (WHO criteria), and 335 controls (age ≥ 60; fasting plasma glucose < 7 mmol/L). E23K genotyping was performed by using molecular beacon‐based real time PCR assays. Results The difference in K or risk allele frequency of cases and controls was significant with an OR of 1.7 (p = 0.0001). The K allele is more common among T2D patients (21%) than in the age and sex matched controls (13.6%). This was consistent with a likely eventual conversion to T2D of younger normoglycemic individuals as they grow older. Conclusions Our results report for the first time a positive association of the E23K variant with T2D in an Arab population. Confirmation by a larger study is indicated. Copyright © 2007 John Wiley & Sons, Ltd.
Editor: Chichester, UK: John Wiley & Sons, Ltd
Idioma: Inglês

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Genetic Study of Saudi Diabetes (GSSD): significant association of the KCNJ11 E23K polymorphism with type 2 diabetes

Alsmadi, Osama ; Al-Rubeaan, Khalid ; Wakil, Salma M. ; Imtiaz, Faiqa ; Mohamed, Gamal ; Al-Saud, Haya ; Al-Saud, Nouran Abu ; Aldaghri, Nasser ; Mohammad, Shahinaz ; Meyer, Brian F

Chichester, UK: John Wiley & Sons, Ltd

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