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Therapeutic potential of resveratrol: the in vivo evidence
Sinclair, David A ; Baur, Joseph A
Nature reviews. Drug discovery, 2006-06, Vol.5 (6), p.493-506
[Periódico revisado por pares]
England: Nature Publishing Group
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Título:
Therapeutic potential of resveratrol: the in vivo evidence
Autor:
Sinclair, David A
;
Baur, Joseph A
Assuntos:
Aging - drug effects
;
Aging - physiology
;
Animals
;
Heart Diseases - drug therapy
;
Heart Diseases - prevention & control
;
Humans
;
Inflammation - drug therapy
;
Inflammation - prevention & control
;
Myocardial Infarction - drug therapy
;
Myocardial Infarction - prevention & control
;
Neoplasms - drug therapy
;
Neoplasms - prevention & control
;
Protective Agents - pharmacology
;
Protective Agents - therapeutic use
;
Stilbenes - pharmacokinetics
;
Stilbenes - pharmacology
;
Stilbenes - therapeutic use
;
Stroke - drug therapy
;
Stroke - prevention & control
;
Vitaceae
É parte de:
Nature reviews. Drug discovery, 2006-06, Vol.5 (6), p.493-506
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
Descrição:
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.
Editor:
England: Nature Publishing Group
Idioma:
Inglês
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