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Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function

KATHIRESAN, Sekar ; GONA, Philimon ; VASAN, Ramachandran S ; LARSON, Martin G ; VITA, Joseph A ; MITCHELL, Gary F ; TOFLER, Geoffrey H ; LEVY, Daniel ; NEWTON-CHEH, Christopher ; WANG, Thomas J ; BENJAMIN, Emelia J

Circulation (New York, N.Y.), 2006-02, Vol.113 (7), p.938-945 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function
Autor: KATHIRESAN, Sekar ; GONA, Philimon ; VASAN, Ramachandran S ; LARSON, Martin G ; VITA, Joseph A ; MITCHELL, Gary F ; TOFLER, Geoffrey H ; LEVY, Daniel ; NEWTON-CHEH, Christopher ; WANG, Thomas J ; BENJAMIN, Emelia J
Assuntos: Aged ; Atrial Natriuretic Factor - blood ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Brachial Artery - physiology ; Cardiology. Vascular system ; Cardiovascular system ; Cross-Sectional Studies ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Endothelium, Vascular - physiology ; Female ; Humans ; Hyperemia - diagnosis ; Inflammation - diagnosis ; Investigative techniques of hemodynamics ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Regional Blood Flow ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Vasodilation
É parte de: Circulation (New York, N.Y.), 2006-02, Vol.113 (7), p.938-945
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Endothelial dysfunction is a critical intermediate phenotype in the pathogenesis of cardiovascular disease. We evaluated the relative contributions of distinct biological pathways to interindividual variation in endothelial function by relating prototype biomarkers (representing these pathways) to brachial artery vasodilator function. We investigated the cross-sectional relations of a panel of 7 biomarkers measured at a routine examination to brachial artery vasodilator function (flow-mediated dilation [FMD] and reactive hyperemia) assessed at a subsequent examination (mean interval, 2.9 years) in 2113 Framingham Heart Study participants (mean age, 61 years; 54% women). We selected biomarkers from 4 biological domains: neurohormonal (N-terminal pro-atrial natriuretic peptide [N-ANP], B-type natriuretic peptide [BNP], renin, aldosterone), hemostatic factors (plasminogen activator inhibitor-1 [PAI-1]), inflammation (C-reactive protein [CRP]), and target organ damage (urine albumin-creatinine ratio). In age- and sex-adjusted models, several biomarkers were related to baseline brachial artery diameter (PAI-1, CRP, urine albumin-creatinine ratio), baseline mean flow (N-ANP, BNP, PAI-1, CRP, aldosterone), FMD (N-ANP, PAI-1, CRP, renin), and reactive hyperemia (BNP, PAI-1, CRP, renin, urine albumin-creatinine ratio). In multivariable analyses relating the 7 biomarkers conjointly to each vascular function measure (adjusting for known risk factors), N-ANP and renin were positively related to FMD (P=0.001 and P=0.04, respectively), and N-ANP was inversely related to baseline mean flow velocity (P=0.01). None of the other biomarkers was significantly related to the vascular function measures studied. In our large community-based sample, a conservative strategy relating several biomarkers to vascular endothelial function identified plasma N-ANP as a key correlate of mean flow under basal conditions and of FMD in response to forearm cuff occlusion.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function

KATHIRESAN, Sekar ; GONA, Philimon ; VASAN, Ramachandran S ; LARSON, Martin G ; VITA, Joseph A ; MITCHELL, Gary F ; TOFLER, Geoffrey H ; LEVY, Daniel ; NEWTON-CHEH, Christopher ; WANG, Thomas J ; BENJAMIN, Emelia J

Hagerstown, MD: Lippincott Williams & Wilkins

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