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Glucocorticoid regulation of the inflammatory response to injury

Yeager, M. P. ; Guyre, P. M. ; Munck, A. U.

Acta anaesthesiologica Scandinavica, 2004-08, Vol.48 (7), p.799-813 [Periódico revisado por pares]

Oxford, UK; Malden, USA: Blackwell Publishing Ltd/Inc

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Título:
Glucocorticoid regulation of the inflammatory response to injury
Autor: Yeager, M. P. ; Guyre, P. M. ; Munck, A. U.
Assuntos: Acute-Phase Reaction ; acute-phase response ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Apoptosis ; Biological and medical sciences ; chemokine ; cortisol ; cytokine ; Glucocorticoid ; Glucocorticoids - pharmacology ; Glucocorticoids - therapeutic use ; Humans ; inflammation ; Inflammation - drug therapy ; Inflammation - immunology ; Inflammation - pathology ; injury ; innate immunity ; macrophage migration inhibition factor ; Macrophage Migration-Inhibitory Factors - physiology ; Medical sciences ; Periodicity ; Pulmonary Surfactant-Associated Protein A - genetics ; receptor ; Receptors, Cytokine - analysis ; sepsis ; Sepsis - drug therapy ; surgery
É parte de: Acta anaesthesiologica Scandinavica, 2004-08, Vol.48 (7), p.799-813
Notas: istex:13A3C61DF9491B74546145F1C6437C5CB351D3A2
ark:/67375/WNG-TG04M9GM-V
ArticleID:AAS434
Supported by NIH grants AI 051547 and AI 053243.
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Descrição: During the first half of the 20th century, physiologists were interested in the adrenal glands primarily because adrenalectomized animals failed to survive even mild degrees of systemic stress. It eventually became clear that hormones secreted by the adrenal cortex were critical for survival and, in this context, adrenal cortical hormones were widely considered to support or stimulate important responses to stress or injury. With the purification and manufacture of adrenal cortical hormones in the 1930s and 1940s, clinicians suddenly discovered the potent anti‐inflammatory actions of glucocorticoids (GCs). This dramatic, and unexpected, discovery has dominated clinical and laboratory research into GC actions throughout the second half of the 20th century. More recent research is again reporting GC‐induced stimulatory effects on a variety of inflammatory response components. These effects are usually observed at low GC concentrations, close to concentrations that are observed in vivo during basal, unstimulated states. For example, GC‐mediated stimulation has been reported for the hepatic acute‐phase response, for cytokine secretion, expression of cytokine/chemokine receptors, and for the pro‐inflammatory mediator, macrophage migration inhibition factor. It seems clear that the long‐held clinical view that GCs act solely as anti‐inflammatory agents needs to be re‐assessed. Varying doses of GCs do not lead simply to varying degrees of inflammation suppression, but rather GCs can exert a full range of effects from permissive to stimulatory to suppressive.
Editor: Oxford, UK; Malden, USA: Blackwell Publishing Ltd/Inc
Idioma: Inglês

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Glucocorticoid regulation of the inflammatory response to injury

Yeager, M. P. ; Guyre, P. M. ; Munck, A. U.

Oxford, UK; Malden, USA: Blackwell Publishing Ltd/Inc

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