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Discovery and genomic analyses of hybridization between divergent lineages of Trypanosoma congolense, causative agent of Animal African Trypanosomiasis

Tihon, Eliane ; Imamura, Hideo ; Dujardin, Jean‐Claude ; Van Den Abbeele, Jan ; Van den Broeck, Frederik

Molecular ecology, 2017-12, Vol.26 (23), p.6524-6538 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Discovery and genomic analyses of hybridization between divergent lineages of Trypanosoma congolense, causative agent of Animal African Trypanosomiasis
Autor: Tihon, Eliane ; Imamura, Hideo ; Dujardin, Jean‐Claude ; Van Den Abbeele, Jan ; Van den Broeck, Frederik
Assuntos: Africa South of the Sahara ; African trypanosomiasis ; Animals ; DNA Copy Number Variations ; Drug resistance ; Gene Deletion ; Gene Frequency ; Genetic variability ; Genetics, Population ; Genome, Protozoan ; Genomes ; Genomic analysis ; Haplotypes ; hybrid swarm ; Hybridization ; Hybridization, Genetic ; INDEL Mutation ; Livestock ; meiotic recombination ; Microsatellite Repeats ; Microsatellites ; nagana ; outcrossing ; Parasites ; Parasitic diseases ; parasitic protozoa ; Pathogenicity ; Pathogens ; Phylogeny ; Polymorphism, Single Nucleotide ; population genomics ; Population studies ; Protozoa ; Single-nucleotide polymorphism ; Trypanosoma congolense ; Trypanosoma congolense - genetics ; Trypanosome ; Trypanosomiasis, African - parasitology ; Trypanosomiasis, African - veterinary ; Vector-borne diseases ; Virulence ; Zambia
É parte de: Molecular ecology, 2017-12, Vol.26 (23), p.6524-6538
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Descrição: Hybrid populations and introgressive hybridization remain poorly documented in pathogenic micro‐organisms, as such that genetic exchange has been argued to play a minor role in their evolution. Recent work demonstrated the existence of hybrid microsatellite profiles in Trypanosoma congolense, a parasitic protozoan with detrimental effects on livestock productivity in sub‐Saharan Africa. Here, we present the first population genomic study of T. congolense, revealing a remarkable number of single nucleotide polymorphisms (SNPs), small insertions/deletions (indels) and gene deletions among 56 parasite genomes from ten African countries. One group of parasites from Zambia was particularly diverse, displaying a substantial number of heterozygous SNP and indel sites compared to T. congolense parasites from the nine other sub‐Saharan countries. Genomewide 5‐kb phylogenetic analyses based on phased SNP data revealed that these parasites were the product of hybridization between phylogenetically distinct T. congolense lineages. Other parasites within the same region in Zambia presented a mosaic of haplotypic ancestry and genetic variability, indicating that hybrid parasites persisted and recombined beyond the initial hybridization event. Our observations challenge traditional views of trypanosome population biology and encourage future research on the role of hybridization in spreading genes for drug resistance, pathogenicity and virulence.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Discovery and genomic analyses of hybridization between divergent lineages of Trypanosoma congolense, causative agent of Animal African Trypanosomiasis

Tihon, Eliane ; Imamura, Hideo ; Dujardin, Jean‐Claude ; Van Den Abbeele, Jan ; Van den Broeck, Frederik

England: Blackwell Publishing Ltd

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