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Evasion and interference: intracellular pathogens modulate caspase-dependent inflammatory responses

Stewart, Mary K ; Cookson, Brad T

Nature reviews. Microbiology, 2016-06, Vol.14 (6), p.346-359 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Evasion and interference: intracellular pathogens modulate caspase-dependent inflammatory responses
Autor: Stewart, Mary K ; Cookson, Brad T
Assuntos: Adaptor proteins ; Animals ; Bacteria ; Bacteria - immunology ; Bacteria - metabolism ; Bacteria - pathogenicity ; Caspase-1 ; Caspase-11 ; Caspase-4 ; Caspase-5 ; Caspases - metabolism ; Cell activation ; Cell death ; Cytokines ; Cytokines - immunology ; Cytoplasm - microbiology ; Cytosol ; Cytosol - immunology ; Enzymatic activity ; Flagellin ; Host-Pathogen Interactions - immunology ; Humans ; IL-1β ; Immune Evasion ; Immunity, Innate ; Inflammasomes ; Inflammasomes - immunology ; Inflammation ; Inflammation - immunology ; Inflammation - physiopathology ; Interleukin ; Interleukin 18 ; Interleukin-18 - immunology ; Interleukin-1beta - immunology ; Intracellular ; Lipopolysaccharides ; Lipopolysaccharides - chemistry ; Localization ; Microorganisms ; Molecular modelling ; Nucleic acids ; Oligomerization ; Pathogens ; Pattern recognition ; Plague ; Priming ; Pyroptosis - immunology ; Receptors ; Viruses ; Viruses - immunology ; Viruses - metabolism ; Viruses - pathogenicity
É parte de: Nature reviews. Microbiology, 2016-06, Vol.14 (6), p.346-359
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
ObjectType-Review-1
Descrição: Pathogens have evolved to complete the virulence cycle of colonization, replication and dissemination in intimate association with a complex network of extracellular and intracellular surveillance systems that guard tissue spaces. In this Review, we discuss the strategies used by bacteria and viruses to evade or inhibit intracellular detection that is coupled to pro-inflammatory caspase-dependent protective responses. Such strategies include alterations of lipopolysaccharide (LPS) structures, the regulated expression of components of type III secretion systems, and the utilization of proteins that inhibit inflammasome formation, the enzymatic activity of caspases and cytokine signalling. Inflammation is crucial in response to exposure to pathogens, but is potentially damaging and thus tightly regulated. The threshold for the activation of pro-inflammatory caspases is determined by the immediate stimulus in the context of previous signals. Pathogen, genetic and situational factors modulate this threshold, which determines the ability of the host to resist infection while minimizing harm.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Evasion and interference: intracellular pathogens modulate caspase-dependent inflammatory responses

Stewart, Mary K ; Cookson, Brad T

England: Nature Publishing Group

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