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Polymeric nanoparticles for targeted drug delivery system for cancer therapy
Masood, Farha
Materials Science & Engineering C, 2016-03, Vol.60, p.569-578
Netherlands: Elsevier B.V
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Título:
Polymeric nanoparticles for targeted drug delivery system for cancer therapy
Autor:
Masood, Farha
Assuntos:
Active control
;
Animals
;
Anticancer drug
;
Antineoplastic Agents - administration & dosage
;
Antineoplastic Agents - chemistry
;
Cancer
;
Cellular
;
Cyclodextrins
;
Drug delivery
;
Drug delivery systems
;
Drug Delivery Systems - methods
;
Humans
;
Materials science
;
Nanoparticles
;
Nanoparticles - chemistry
;
Neoplasms - drug therapy
;
Polymer
;
Polymers - chemistry
;
Receptor
;
Site specific target
;
Therapy
É parte de:
Materials Science & Engineering C, 2016-03, Vol.60, p.569-578
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição:
A targeted delivery system based on the polymeric nanoparticles as a drug carrier represents a marvelous avenue for cancer therapy. The pivotal characteristics of this system include biodegradability, biocompatibility, non-toxicity, prolonged circulation and a wide payload spectrum of a therapeutic agent. Other outstanding features are their distinctive size and shape properties for tissue penetration via an active and passive targeting, specific cellular/subcellular trafficking pathways and facile control of cargo release by sophisticated material engineering. In this review, the current implications of encapsulation of anticancer agents within polyhydroxyalkanoates, poly-(lactic-co-glycolic acid) and cyclodextrin based nanoparticles to precisely target the tumor site, i.e., cell, tissue and organ are highlighted. Furthermore, the promising perspectives in this emerging field are discussed. [Display omitted] •Targeted drug delivery system (TDDS) is applied to precisely target and treat the tumors.•Polymeric nanoparticles (PNPs) are used as carrier of anticancer agents in TDDS.•The current progress in uses of PNPs in TDDS is addressed in this review.
Editor:
Netherlands: Elsevier B.V
Idioma:
Inglês
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