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Can donepezil facilitate weaning from mechanical ventilation in difficult to wean patients? An interventional pilot study

Abbasi, Saeed ; Farsaei, Shadi ; Fazel, Kamran ; Golzari, Samad E J ; Mahmoodpoor, Ata

Daru, 2015-03, Vol.23 (3), p.1-1 [Periódico revisado por pares]

New York: Springer Nature B.V

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  • Título:
    Can donepezil facilitate weaning from mechanical ventilation in difficult to wean patients? An interventional pilot study
  • Autor: Abbasi, Saeed ; Farsaei, Shadi ; Fazel, Kamran ; Golzari, Samad E J ; Mahmoodpoor, Ata
  • Assuntos: Acquisitions & mergers ; Electrolytes ; Intervention ; Mortality ; Respiration ; Sleep apnea ; Statistical analysis ; Stimulants ; Studies
  • É parte de: Daru, 2015-03, Vol.23 (3), p.1-1
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: In this paper, the authors evaluated the efficacy of using donepezil on weaning course in difficult to wean patients. In this non-randomized interventional clinical study, difficult to wean patients with prior inappropriately depressed respiratory responses were included from two referral intensive care units in Iran. Patients with another potentially reasons of weaning failure were excluded from the study. Donepezil was started for eligible patients at dose of 10 mg daily for 2-4 weeks. For the primary outcomes, arterial blood gas (ABG) parameters were also measured before and after intervention to evaluate the possible effects of donepezil on them. Twelve out of 16 studied patients experienced successful results to facilitate weaning with donepezil intervention. The mean duration of donepezil treatment until outcome measurement was 12 days. There were not any significant differences in ABG parameters among patients with successful and failed weaning trial on day of donepezil initiation.
  • Editor: New York: Springer Nature B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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