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Thermal physiology of laboratory mice: Defining thermoneutrality

Gordon, C.J.

Journal of thermal biology, 2012-12, Vol.37 (8), p.654-685 [Periódico revisado por pares]

Elsevier Ltd

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  • Título:
    Thermal physiology of laboratory mice: Defining thermoneutrality
  • Autor: Gordon, C.J.
  • Assuntos: Aging ; Ambient temperature ; Brown adipose tissue ; Core temperature ; Diseases ; Evaporative water loss ; Fever ; Growth ; Huddling ; Mathematical models ; Metabolic rate ; Mice ; Physiology ; Reproduction ; Selected temperature ; Telemetry ; Thermal comfort ; Thermal conductance ; Thermoregulation
  • É parte de: Journal of thermal biology, 2012-12, Vol.37 (8), p.654-685
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
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  • Descrição: In terms of total number of publications, the laboratory mouse (Mus musculus) has emerged as the most popular test subject in biomedical research. Mice are used as models to study obesity, diabetes, CNS diseases and variety of other pathologies. Mice are classified as homeotherms and regulate their core temperature over a relatively wide range of ambient temperatures. However, researchers find that the thermoregulatory system of mice is easily affected by drugs, chemicals, and a variety of pathological conditions, effects that can be exacerbated by changes in ambient temperature. To this end, a thorough review of the thermal physiology of mice, including their sensitivity and regulatory limits to changes in ambient temperature is the primary focus of this review. Specifically, the zone of thermoneutrality for metabolic rate and how it corresponds to that for growth, reproduction, development, thermal comfort, and many other variables is covered. A key point of the review is to show that behavioral thermoregulation of mice is geared to minimize energy expenditure. Their zone of thermal comfort is essentially wedged between the thresholds to increase heat production and heat loss; however, this zone is above the recommended guidelines for animal vivariums. Future work is needed to better understand the behavioral and autonomic thermoregulatory responses of this most popular test species. ► Laboratory mice have become the predominant test species in most disciplines of biomedicine. ► Mice are housed at temperatures that subject them to moderate cold stress. ► Their temperature and metabolisms stability is susceptible to a variety of drugs and pathological conditions. ► This review focuses on the thermoneutral zone of laboratory mice. ► The impact of temperature on growth, reproduction, organ development, and behavior is explored in detail.
  • Editor: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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