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Colorectal cancer pulmonary oligometastases: pooled analysis and construction of a clinical lung metastasectomy prognostic model

Salah, S. ; Watanabe, K. ; Welter, S. ; Park, J.S. ; Park, J.W. ; Zabaleta, J. ; Ardissone, F. ; Kim, J. ; Riquet, M. ; Nojiri, K. ; Gisabella, M. ; Kim, S.Y. ; Tanaka, K. ; Al-Haj Ali, B.

Annals of oncology, 2012-10, Vol.23 (10), p.2649-2655 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Colorectal cancer pulmonary oligometastases: pooled analysis and construction of a clinical lung metastasectomy prognostic model
Autor: Salah, S. ; Watanabe, K. ; Welter, S. ; Park, J.S. ; Park, J.W. ; Zabaleta, J. ; Ardissone, F. ; Kim, J. ; Riquet, M. ; Nojiri, K. ; Gisabella, M. ; Kim, S.Y. ; Tanaka, K. ; Al-Haj Ali, B.
Assuntos: Antineoplastic agents ; Biological and medical sciences ; colorectal cancer ; Colorectal Neoplasms - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Lung Neoplasms - secondary ; Male ; Medical sciences ; metastasectomy ; Models, Biological ; Pharmacology. Drug treatments ; Pneumology ; Prognosis ; prognostic factors ; pulmonary metastasis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors ; Tumors of the respiratory system and mediastinum
É parte de: Annals of oncology, 2012-10, Vol.23 (10), p.2649-2655
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Although resecting colorectal cancer (CRC) pulmonary metastasis is associated with long-term survival, identification of prognostic groups is needed for future randomized trials, and construction of a lung metastasectomy prognostic model (LMPM) is warranted. We searched the PubMed database for retrospective studies evaluating prognostic factors following resecting CRC lung metastasis. Individual patient data were analyzed. Independent prognostic factors were used to construct an LMPM. Between 1983 and 2008, 1112 metastasectomies were carried out on 927 patients included in eight studies. Five-year survival rate was 54.3% following the first lung resection. Multivariate analysis identified three independently poor prognostic factors: pre-thoracotomy carcinoembryonic antigen ≥5 ng/ml, disease-free interval <36 months, and more than one metastatic lesion. Patients with good-, intermediate-, and high-risk groups according to the LMPM had a 5-year survival of 68.2%, 46.4%, and 26.1%, respectively (P < 0.001). Perioperative chemotherapy and previously resected liver metastasis had no influence on survival. The low- and intermediate-risk groups have a good chance of long-term survival following metastasectomy. However, more studies are needed to investigate whether surgery offers any advantage over systemic therapy for the poor-risk group.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Colorectal cancer pulmonary oligometastases: pooled analysis and construction of a clinical lung metastasectomy prognostic model

Salah, S. ; Watanabe, K. ; Welter, S. ; Park, J.S. ; Park, J.W. ; Zabaleta, J. ; Ardissone, F. ; Kim, J. ; Riquet, M. ; Nojiri, K. ; Gisabella, M. ; Kim, S.Y. ; Tanaka, K. ; Al-Haj Ali, B.

Oxford: Elsevier Ltd

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