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Impact of Prolonged Temporal Discrimination Threshold on Finger Movements of Parkinson's Disease

Lee, M J ; Son, J S ; Lee, J H ; Kim, S J ; Lyoo, C H ; Lee, M S Tremblay, François

PloS one, 2016-11, Vol.11 (11), p.e0167034-e0167034 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Impact of Prolonged Temporal Discrimination Threshold on Finger Movements of Parkinson's Disease
Autor: Lee, M J ; Son, J S ; Lee, J H ; Kim, S J ; Lyoo, C H ; Lee, M S
Tremblay, François
Assuntos: Aged ; Aged, 80 and over ; Analysis ; Basal ganglia ; Biology and Life Sciences ; Biomechanical Phenomena ; Biomedical research ; Brain research ; Case-Control Studies ; Central nervous system diseases ; Dextrous fingers ; Discrimination (Psychology) ; Disease control ; DNA nucleotidylexotransferase ; Dopamine ; Female ; Finger ; Fingers ; Fingers - physiopathology ; Health aspects ; Human mechanics ; Humans ; Inertial sensing devices ; Kinematics ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Motor task performance ; Movement ; Movement (Physiology) ; Movement disorders ; Neurodegenerative diseases ; Neurology ; Neurosciences ; Parkinson disease ; Parkinson Disease - physiopathology ; Parkinson's disease ; Physical Sciences ; Physiological aspects ; Psychomotor Performance ; Sensory deprivation ; Studies ; Temporal discrimination ; Temporal perception ; Variability
É parte de: PloS one, 2016-11, Vol.11 (11), p.e0167034-e0167034
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceptualization: MSL. Formal analysis: MJL JSS. Funding acquisition: MJL. Investigation: MJL. Methodology: MJL JHL SJK CHL. Resources: MJL. Software: JSS. Supervision: MSL. Writing – original draft: MJL. Writing – review & editing: SJK JHL CHL MSL.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Sensory information is essential for the precise control of movement. Patients with Parkinson's disease (PD) have higher-order sensory dysfunctions including prolonged temporal discrimination threshold (TDT). However, the impact of prolonged TDT on parkinsonian motor deficits is uncertain. This study includes 33 PD patients and 24 healthy controls. TDT values were measured in the index finger. Using coin rotation task (CRT), dexterous finger movement was assessed. Using an inertial sensor, the speed, amplitude, and frequency of finger tapping were measured. The impact of prolonged index finger TDT on two different finger movements was analyzed using the general estimating equation. Compared to healthy controls, TDT was prolonged in the PD patients. There was no impact of TDT on mean values or decrement for amplitude and speed, as well as mean values, decrement and variability of tapping frequency. However, prolonged TDT had a significant impact on the variability in amplitude (B = 436.905 × 10-4, Wald χ2 = 9.140, p = 0.014) and speed (B = 425.655 × 10-4, Wald χ2 = 9.876, p = 0.014) of finger tapping. There was a marginal correlation between TDT and CRT. In addition, CRT correlated with variability in amplitude and speed of finger tapping. In PD, cutaneous temporal discriminative sensory dysfunction appears to be related to increased variabilities in the speed and amplitude of fast repetitive finger movements and disturbed finger dexterity.
Editor: United States: Public Library of Science
Idioma: Inglês

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Impact of Prolonged Temporal Discrimination Threshold on Finger Movements of Parkinson's Disease

Lee, M J ; Son, J S ; Lee, J H ; Kim, S J ; Lyoo, C H ; Lee, M S Tremblay, François

United States: Public Library of Science

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