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High resolution T1ρ mapping of in vivo human knee cartilage at 7T

Singh, Anup ; Haris, Mohammad ; Cai, Kejia ; Kogan, Feliks ; Hariharan, Hari ; Reddy, Ravinder Zadpoor, Amir A.

PloS one, 2014-05, Vol.9 (5), p.e97486-e97486 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
High resolution T1ρ mapping of in vivo human knee cartilage at 7T
Autor: Singh, Anup ; Haris, Mohammad ; Cai, Kejia ; Kogan, Feliks ; Hariharan, Hari ; Reddy, Ravinder
Zadpoor, Amir A.
Assuntos: Adult ; Advantages ; Arthritis ; Biocompatibility ; Biology and Life Sciences ; Biomedical materials ; Cartilage ; Cartilage diseases ; Cartilage, Articular - anatomy & histology ; Cartilage, Articular - pathology ; Change detection ; Electric potential ; Feasibility studies ; Field strength ; High resolution ; Human subjects ; Humans ; Image processing ; Image Processing, Computer-Assisted - methods ; Image resolution ; Imaging, Three-Dimensional ; In vivo methods and tests ; Knee ; Knee - pathology ; Knee Joint - pathology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Mapping ; Medicine and Health Sciences ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Osteoarthritis ; Osteoarthritis, Knee - diagnosis ; Osteoarthritis, Knee - physiopathology ; Relaxation time ; Reliability analysis ; Reproducibility of Results ; Scanners ; Signal-To-Noise Ratio ; Studies ; Values ; Voltage ; Young Adult
É parte de: PloS one, 2014-05, Vol.9 (5), p.e97486-e97486
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: AS HH RR. Performed the experiments: AS MH KC FK. Analyzed the data: AS MH KC FK. Contributed reagents/materials/analysis tools: AS MH KC FK. Wrote the paper: AS MH KC FK HH RR. Designed the software used in analysis: AS.
Descrição: Spin lattice relaxation time in rotating frame (T1ρ) mapping of human knee cartilage has shown promise in detecting biochemical changes during osteoarthritis. Due to higher field strength, MRI at 7T has advantages in term of SNR compared to clinical MR scanners and this can be used to increase in image resolution. Objective of current study was to evaluate the feasibility of high resolution T1ρ mapping of in vivo human knee cartilage at 7T MR scanner. In this study we have used a T1ρ prepared GRE pulse sequence for obtaining high resolution (in plan resolution = 0.2 mm2) T1ρ MRI of human knee cartilage at 7T. The effect of a global and localized reference frequency and reference voltage setting on B0, B1 and T1ρ maps in cartilage was evaluated. Test-retest reliability results of T1ρ values from asymptomatic subjects as well as T1ρ maps from abnormal cartilage of two human subjects are presented. These results are compared with T1ρ MRI data obtained from 3T. Our approach enabled acquisition of 3D-T1ρ data within allowed SAR limits at 7T. SNR of cartilage on T1ρ weighted images was greater than 90. Off-resonance effects present in the cartilage B0, B1 and T1ρ maps obtained using global shim and reference frequency and voltage setting, were reduced by the proposed localized reference frequency and voltage setting. T1ρ values of cartilage obtained with the localized approach were reproducible. Abnormal knee cartilage showed elevated T1ρ values in affected regions. T1ρ values at 7T were significantly lower (p<0.05) compared to those obtained at 3T. In summary, by using proposed localized frequency and voltage setting approach, high-resolution 3D-T1ρ maps of in vivo human knee cartilage can be obtained in clinically acceptable scan times (<30 min) and SAR constraints, which provides the ability to characterize cartilage molecular integrity.
Editor: United States: Public Library of Science
Idioma: Inglês

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High resolution T1ρ mapping of in vivo human knee cartilage at 7T

Singh, Anup ; Haris, Mohammad ; Cai, Kejia ; Kogan, Feliks ; Hariharan, Hari ; Reddy, Ravinder Zadpoor, Amir A.

United States: Public Library of Science

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