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Why are sensory axons more vulnerable for ischemia than motor axons?

Hofmeijer, Jeannette ; Franssen, Hessel ; van Schelven, Leonard J ; van Putten, Michel J A M Mongin, Alexander A.

PloS one, 2013-06, Vol.8 (6), p.e67113-e67113 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Why are sensory axons more vulnerable for ischemia than motor axons?
Autor: Hofmeijer, Jeannette ; Franssen, Hessel ; van Schelven, Leonard J ; van Putten, Michel J A M
Mongin, Alexander A.
Assuntos: Action Potentials ; Adult ; Arm - blood supply ; Arm - physiopathology ; Axons ; Axons - physiology ; Biology ; Cell Hypoxia ; Conductance ; Deactivation ; Depolarization ; Diabetes ; Diabetic neuropathy ; Electrodes ; Excitability ; Experiments ; Female ; Forearm ; Humans ; Inactivation ; Ion channels ; Ischemia ; Ischemia - physiopathology ; Male ; Measurement methods ; Median nerve ; Medicine ; Middle Aged ; Motor neurons ; Motor Neurons - physiology ; Muscles ; Nerve conduction ; Neural Conduction ; Neurology ; Neurosciences ; Proprioception ; Refractory period ; Resistance ; Sensory neurons ; Sensory Receptor Cells - physiology ; Sodium conductance ; Studies ; Time constant
É parte de: PloS one, 2013-06, Vol.8 (6), p.e67113-e67113
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: JH HF LJvS MJAMvP. Performed the experiments: JH HF LJvS MJAMvP. Analyzed the data: JH HF LJvS MJAMvP. Contributed reagents/materials/analysis tools: JH HF LJvS MJAMvP. Wrote the paper: JH HF LJvS MJAMvP.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: In common peripheral neuropathies, sensory symptoms usually prevail over motor symptoms. This predominance of sensory symptoms may result from higher sensitivity of sensory axons to ischemia. We measured median nerve compound sensory action potentials (CSAPs), compound muscle action potentials (CMAPs), and excitability indices in five healthy subjects during forearm ischemia lasting up to disappearance of both CSAPs and CMAPs. ISCHEMIA INDUCED: (1) earlier disappearance of CSAPs than CMAPs (mean ± standard deviation 30±5 vs. 46±6 minutes), (2) initial changes compatible with axonal depolarization on excitability testing (decrease in threshold, increase in strength duration time constant (SDTC) and refractory period, and decrease in absolute superexcitability) which were all more prominent in sensory than in motor axons, and (3) a subsequent decrease of SDTC reflecting a decrease in persistent Na(+) conductance during continuing depolarisation. Our study shows that peripheral sensory axons are more vulnerable for ischemia than motor axons, with faster inexcitability during ischemia. Excitability studies during ischemia showed that this was associated with faster depolarization and faster persistent Na(+) channel inactivation in sensory than in motor axons. These findings might be attributed to differences in ion channel composition between sensory and motor axons and may contribute to the predominance of sensory over motor symptoms in common peripheral neuropathies.
Editor: United States: Public Library of Science
Idioma: Inglês

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Why are sensory axons more vulnerable for ischemia than motor axons?

Hofmeijer, Jeannette ; Franssen, Hessel ; van Schelven, Leonard J ; van Putten, Michel J A M Mongin, Alexander A.

United States: Public Library of Science

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