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Radiotherapy of the R1H-tumor : dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators

KLEINEIDAM, M ; GUTHOFF, R ; SCHILLER, F ; CHUMBLEY, L ; BECK-BORNHOLDT, H.-P

International journal of radiation oncology, biology, physics, 1993-01, Vol.25 (2), p.277-281 [Periódico revisado por pares]

New York, NY: Elsevier

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Título:
Radiotherapy of the R1H-tumor : dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators
Autor: KLEINEIDAM, M ; GUTHOFF, R ; SCHILLER, F ; CHUMBLEY, L ; BECK-BORNHOLDT, H.-P
Assuntos: Animals ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL MODELS ; BODY ; BODY AREAS ; Brachytherapy - instrumentation ; CARCINOMAS ; DISEASES ; DOSE RATES ; ELEMENTS ; EPITHELIOMAS ; EVEN-EVEN NUCLEI ; EYES ; FACE ; Female ; HEAD ; INTERMEDIATE MASS NUCLEI ; ISOTOPES ; Medical sciences ; MEDICINE ; MELANOMAS ; Miscellaneous ; Neoplasm Transplantation ; NEOPLASMS ; NONMETALS ; NUCLEAR MEDICINE ; NUCLEI ; ORGANS ; OXYGEN ; RADIOISOTOPES ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy Dosage ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Rats ; Rhabdomyosarcoma - radiotherapy ; RUTHENIUM 106 ; RUTHENIUM ISOTOPES ; Ruthenium Radioisotopes - administration & dosage ; Ruthenium Radioisotopes - therapeutic use ; SENSE ORGANS ; THERAPY ; TIME DEPENDENCE ; YEARS LIVING RADIOISOTOPES 550603 -- Medicine-- External Radiation in Therapy-- (1980-)
É parte de: International journal of radiation oncology, biology, physics, 1993-01, Vol.25 (2), p.277-281
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The influence of the dose-rate on tumor response in radiotherapy with 106-Ruthenium eye plaques has been investigated in an experimental tumor system. The identical total dose was applied within three different overall treatment times (42 hr, 192 hr and 312 hr), corresponding to dose-rates of 6.0 Gy/hr, 1.3 Gy/hr and 0.8 Gy/hr. The therapeutic outcome of brachytherapy varied significantly between the three groups of animals treated with different dose-rates. At a dose-rate of 1.3 Gy/hr all tumors were locally controlled, but no local control was observed when a dose-rate of 6.0 Gy/hr was delivered. 0.8 Gy/hr was less effective than 1.3 Gy/hr but more effective than 6.0 Gy/hr. These results were unexpected but they might be explained by an incomplete reoxygenation if the overall treatment time is too short (42 hr, dose-rate 6.0 Gy/hr) and by proliferation of tumor cells under treatment if the overall treatment time is too long (312 hr, 0.8 Gy/hr).
Editor: New York, NY: Elsevier
Idioma: Inglês

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Radiotherapy of the R1H-tumor : dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators

KLEINEIDAM, M ; GUTHOFF, R ; SCHILLER, F ; CHUMBLEY, L ; BECK-BORNHOLDT, H.-P

New York, NY: Elsevier

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