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miR-372 Regulates Cell Cycle and Apoptosis of AGS Human Gastric Cancer Cell Line through Direct Regulation of LATS2

Cho, W.J., University of Ulsan, Ulsan, Republic of Korea ; Shin, J.M., Hanyang University, Seoul, Republic of Korea ; Kim, J.S., Hanyang University, Seoul, Republic of Korea ; Lee, M.R., Hanyang University, Seoul, Republic of Korea ; Hong, K.S., Hanyang University, Seoul, Republic of Korea ; Lee, J.H., Hanyang University, Seoul, Republic of Korea ; Koo, K.H., Hanyang University, Seoul, Republic of Korea ; Park, J.W., University of Ulsan, Ulsan, Republic of Korea ; Kim, K.S., Hanyang University, Seoul, Republic of Korea

Molecules and Cells, 2009, 28(6), , pp.521-527 [Periódico revisado por pares]

Springer: Korean Society for Molecular and Cellular Biology

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Título:
miR-372 Regulates Cell Cycle and Apoptosis of AGS Human Gastric Cancer Cell Line through Direct Regulation of LATS2
Autor: Cho, W.J., University of Ulsan, Ulsan, Republic of Korea ; Shin, J.M., Hanyang University, Seoul, Republic of Korea ; Kim, J.S., Hanyang University, Seoul, Republic of Korea ; Lee, M.R., Hanyang University, Seoul, Republic of Korea ; Hong, K.S., Hanyang University, Seoul, Republic of Korea ; Lee, J.H., Hanyang University, Seoul, Republic of Korea ; Koo, K.H., Hanyang University, Seoul, Republic of Korea ; Park, J.W., University of Ulsan, Ulsan, Republic of Korea ; Kim, K.S., Hanyang University, Seoul, Republic of Korea
Assuntos: Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; AGS gastric cancer cell line ; APOPTOSE ; APOPTOSIS ; Apoptosis - genetics ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Cell Biology ; CELL CYCLE ; Cell Cycle - genetics ; Cell Line, Tumor ; Cell Proliferation ; CICLO CELULAR ; CYCLE CELLULAIRE ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Humans ; Life Sciences ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Protein Serine-Threonine Kinases - genetics ; Protein Serine-Threonine Kinases - metabolism ; RNA, Small Interfering - genetics ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Tumor Suppressor Proteins - genetics ; Tumor Suppressor Proteins - metabolism ; 생물학
É parte de: Molecules and Cells, 2009, 28(6), , pp.521-527
Notas: A50
2010000325
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SourceType-Scholarly Journals-1
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G704-000079.2009.28.6.007
Descrição: Previously, we have reported tissue- and stage-specific expression of miR-372 in human embryonic stem cells and so far, not many reports speculate the function of this microRNA (miRNA). In this study, we screened various human cancer cell lines including gastric cancer cell lines and found first time that miR-372 is expressed only in AGS human gastric adenocarcinoma cell line. Inhibition of miR-372 using antisense miR-372 oligonucleotide (AS-miR-372) suppressed proliferation, arrested the cell cycle at G2/M phase, and increased apoptosis of AGS cells. Furthermore, AS-miR-372 treatment increased expression of LATS2, while over-expression of miR-372 decreased luciferase reporter activity driven by the 3' untranslated region (3' UTR) of LATS2 mRNA. Over-expression of LATS2 induced changes in AGS cells similar to those in AGS cells treated with AS-miR-372. Taken together, these findings demonstrate an oncogenic role for miR-372 in controlling cell growth, cell cycle, and apoptosis through down-regulation of a tumor suppressor gene, LATS2.
Editor: Springer: Korean Society for Molecular and Cellular Biology
Idioma: Inglês

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miR-372 Regulates Cell Cycle and Apoptosis of AGS Human Gastric Cancer Cell Line through Direct Regulation of LATS2

Springer: Korean Society for Molecular and Cellular Biology

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