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7. Effect of Foot Shock Stress on The Activation of Skin Mast Cell in Mice

Zaifu Liang ; Mirei Katayama ; Eri Aoki ; Minori Kono ; Masatoshi Nagano ; Hidenori Suzuki ; Seiji Kawana

Journal of Nippon Medical School, 2003, Vol.70 (2), p.193-193 [Periódico revisado por pares]

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Título:
7. Effect of Foot Shock Stress on The Activation of Skin Mast Cell in Mice
Autor: Zaifu Liang ; Mirei Katayama ; Eri Aoki ; Minori Kono ; Masatoshi Nagano ; Hidenori Suzuki ; Seiji Kawana
É parte de: Journal of Nippon Medical School, 2003, Vol.70 (2), p.193-193
Descrição: Stress induces various changes in the nerve, endocrine, and immune systems, and significantly influences skin diseases and cutaneous function through neuroimmunocutaneous system. In this study, female C 57 BL/6 mice were used to elucidate the effect of foot shock stress on skin neuropeptides and mast cells. Dorsal skin NGF and SP were detected by methods of immunochemical staining and two site ELISA. The NGF, SP and GDNF concentrations in plasma were measured by radioimmunoassy. It was found that there were increasing activation of mast cell (the peak of activation was seen on the 5 th day), decreasing tendency of SP and increasing tendency of GDNF in skin after foot shock stress. The pretreatment with NGF antagonist ALE-0540 and NK 1 antagonist WIN 51078 inhibited the activation of mast cells. The results showed that foot shock stress might expression the change of neuropeptides and activation, of mast cells in skin, and the antagonists of NGF and SP may have an antihypersensitivity effect.
Editor: The Medical Association of Nippon Medical School
Idioma: Japonês

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