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New Isocoumarins from the Marine Fungus IPhaeosphaeriopsis/I sp. WP-26

Wang, Pei ; Wang, Huifang ; Yang, Juchun ; Yang, Li ; Cai, Caihong ; Yuan, Jingzhe ; Wu, Fei ; Gai, Cuijuan ; Mei, Wenli ; Dai, Haofu

Marine drugs, 2023-02, Vol.21 (3) [Periódico revisado por pares]

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Título:
New Isocoumarins from the Marine Fungus IPhaeosphaeriopsis/I sp. WP-26
Autor: Wang, Pei ; Wang, Huifang ; Yang, Juchun ; Yang, Li ; Cai, Caihong ; Yuan, Jingzhe ; Wu, Fei ; Gai, Cuijuan ; Mei, Wenli ; Dai, Haofu
Assuntos: Fungi
É parte de: Marine drugs, 2023-02, Vol.21 (3)
Descrição: Five new isocoumarins, phaeosphaerins A–E (1–5), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (6), and two known pimarane-type diterpenes, diaportheins A (7) and B (8). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds 1–7 displayed weak neuroprotective effects against H[sub.2]O[sub.2]-induced damage in SH-SY5Y cells. Moreover, compound 8 showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.
Editor: MDPI AG
Idioma: Inglês

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