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Control of Hepatitis B Virus by Cytokines

Xia, Yuchen ; Protzer, Ulrike

Viruses, 2017-01, Vol.9 (1), p.18 [Periódico revisado por pares]

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Título:
Control of Hepatitis B Virus by Cytokines
Autor: Xia, Yuchen ; Protzer, Ulrike
Assuntos: cccDNA ; cytokine ; Cytokines - metabolism ; Hepatitis B - immunology ; Hepatitis B - virology ; hepatitis B virus (HBV) ; Hepatitis B virus - immunology ; Host-Pathogen Interactions ; Humans ; interferon ; interferon-induced gene (ISG) ; Review ; therapy
É parte de: Viruses, 2017-01, Vol.9 (1), p.18
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
Descrição: Hepatitis B virus (HBV) infection remains a major public health problem worldwide with more than 240 million individuals chronically infected. Current treatments can control HBV replication to a large extent, but cannot eliminate HBV infection. Cytokines have been shown to control HBV replication and contribute to HBV cure in different models. Cytokines play an important role in limiting acute HBV infection in patients and mediate a non-cytolytic clearance of the virus. In this review, we summarize the effects of cytokines and cytokine-induced cellular signaling pathways on different steps of the HBV life cycle, and discuss possible strategies that may contribute to the eradication of HBV through innate immune activation.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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