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Obesity-associated changes in molecular biology of primary breast cancer

Nguyen, Ha-Linh ; Geukens, Tatjana ; Maetens, Marion ; Aparicio, Samuel ; Bassez, Ayse ; Borg, Ake ; Brock, Jane ; Broeks, Annegien ; Caldas, Carlos ; Cardoso, Fatima ; De Schepper, Maxim ; Delorenzi, Mauro ; Drukker, Caroline A ; Glas, Annuska M ; Green, Andrew R ; Isnaldi, Edoardo ; Eyfjörð, Jórunn ; Khout, Hazem ; Knappskog, Stian ; Krishnamurthy, Savitri ; Lakhani, Sunil R ; Langerod, Anita ; Martens, John W M ; McCart Reed, Amy E ; Murphy, Leigh ; Naulaerts, Stefan ; Nik-Zainal, Serena ; Nevelsteen, Ines ; Neven, Patrick ; Piccart, Martine ; Poncet, Coralie ; Punie, Kevin ; Purdie, Colin ; Rakha, Emad A ; Richardson, Andrea ; Rutgers, Emiel ; Vincent-Salomon, Anne ; Simpson, Peter T ; Schmidt, Marjanka K ; Sotiriou, Christos ; Span, Paul N ; Tan, Kiat Tee Benita ; Thompson, Alastair ; Tommasi, Stefania ; Van Baelen, Karen ; Van de Vijver, Marc ; Van Laere, Steven ; Van't Veer, Laura ; Viale, Giuseppe ; Viari, Alain ; Vos, Hanne ; Witteveen, Anke T ; Wildiers, Hans ; Floris, Giuseppe ; Garg, Abhishek D ; Smeets, Ann ; Lambrechts, Diether ; Biganzoli, Elia ; Richard, François ; Desmedt, Christine

Nature communications, 2023-07, Vol.14 (1), p.4418-4418 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Obesity-associated changes in molecular biology of primary breast cancer
Autor: Nguyen, Ha-Linh ; Geukens, Tatjana ; Maetens, Marion ; Aparicio, Samuel ; Bassez, Ayse ; Borg, Ake ; Brock, Jane ; Broeks, Annegien ; Caldas, Carlos ; Cardoso, Fatima ; De Schepper, Maxim ; Delorenzi, Mauro ; Drukker, Caroline A ; Glas, Annuska M ; Green, Andrew R ; Isnaldi, Edoardo ; Eyfjörð, Jórunn ; Khout, Hazem ; Knappskog, Stian ; Krishnamurthy, Savitri ; Lakhani, Sunil R ; Langerod, Anita ; Martens, John W M ; McCart Reed, Amy E ; Murphy, Leigh ; Naulaerts, Stefan ; Nik-Zainal, Serena ; Nevelsteen, Ines ; Neven, Patrick ; Piccart, Martine ; Poncet, Coralie ; Punie, Kevin ; Purdie, Colin ; Rakha, Emad A ; Richardson, Andrea ; Rutgers, Emiel ; Vincent-Salomon, Anne ; Simpson, Peter T ; Schmidt, Marjanka K ; Sotiriou, Christos ; Span, Paul N ; Tan, Kiat Tee Benita ; Thompson, Alastair ; Tommasi, Stefania ; Van Baelen, Karen ; Van de Vijver, Marc ; Van Laere, Steven ; Van't Veer, Laura ; Viale, Giuseppe ; Viari, Alain ; Vos, Hanne ; Witteveen, Anke T ; Wildiers, Hans ; Floris, Giuseppe ; Garg, Abhishek D ; Smeets, Ann ; Lambrechts, Diether ; Biganzoli, Elia ; Richard, François ; Desmedt, Christine
Assuntos: Adipose tissue ; Biology ; Body mass ; Body mass index ; Body size ; Body weight ; Breast cancer ; Breast Neoplasms ; Breast Neoplasms - genetics ; breast tumor ; Cancer ; Cancer and Oncology ; Cancer och onkologi ; cell component ; Clinical Medicine ; cohort analysis ; complication ; controlled study ; Data collection ; Endocrinology and metabolism ; estrogen receptor ; Estrogen receptors ; Estrogens ; Female ; Genetics ; Genomics ; health risk ; Heterogeneity ; human ; Human genetics ; Human health and pathology ; human tissue ; Humans ; inflammation ; Klinisk medicin ; Life Sciences ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Molecular Biology ; obese patient ; Obesity ; Obesity - complications ; Obesity - genetics ; Overweight ; Phenotypes ; primary tumor ; risk factor ; Santé publique et épidémiologie ; single cell analysis ; Transcriptomics ; tumor ; Tumor Microenvironment ; Tumors
É parte de: Nature communications, 2023-07, Vol.14 (1), p.4418-4418
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC differs according to patients' body mass index (BMI) using data from >2,000 patients. We identify several genomic alterations that are differentially prevalent in overweight or obese patients compared to lean patients. We report evidence supporting an ageing accelerating effect of obesity at the genetic level. We show that BMI-associated differences in bulk transcriptomic profile are subtle, while single cell profiling allows detection of more pronounced changes in different cell compartments. These analyses further reveal an elevated and unresolved inflammation of the BC tumor microenvironment associated with obesity, with distinct characteristics contingent on the estrogen receptor status. Collectively, our analyses imply that obesity is associated with an inflammaging-like phenotype. We conclude that patient adiposity may play a significant role in the heterogeneity of BC and should be considered for BC treatment tailoring.
Editor: England: Nature Publishing Group
Idioma: Inglês;Norueguês

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Obesity-associated changes in molecular biology of primary breast cancer

England: Nature Publishing Group

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