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Organoids: a promising new in vitro platform in livestock and veterinary research

Kar, Soumya K ; Wells, Jerry M ; Ellen, Esther D ; Te Pas, Marinus F W ; Madsen, Ole ; Groenen, Martien A M ; Woelders, Henri

Veterinary research (Paris), 2021-03, Vol.52 (1), p.43-43, Article 43 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Organoids: a promising new in vitro platform in livestock and veterinary research
Autor: Kar, Soumya K ; Wells, Jerry M ; Ellen, Esther D ; Te Pas, Marinus F W ; Madsen, Ole ; Groenen, Martien A M ; Woelders, Henri
Assuntos: Animal behavior ; Animal biology ; Animal breeding and genomics ; Animal health ; Animal Husbandry - methods ; Animal nutrition ; Animal Nutritional Physiological Phenomena ; Animals ; Biotechnology ; Biotechnology - methods ; Breeding - methods ; Collagen ; Embryonic stem cells ; Gene expression ; Genetic engineering ; Genomics - methods ; Growth factors ; Heparan sulfate ; Host Microbial Interactions ; Host-microbe interaction ; In vitro model ; In Vitro Techniques - methods ; In Vitro Techniques - veterinary ; Life Sciences ; Livestock ; Organoids ; Organoids - physiology ; Pets ; Physiology ; Poultry ; Review ; Stem cell research ; Stem cells ; Veterinary Medicine - methods ; Veterinary medicine and animal Health
É parte de: Veterinary research (Paris), 2021-03, Vol.52 (1), p.43-43, Article 43
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
ObjectType-Review-1
Descrição: Organoids are self-organizing, self-renewing three-dimensional cellular structures that resemble organs in structure and function. They can be derived from adult stem cells, embryonic stem cells, or induced pluripotent stem cells. They contain most of the relevant cell types with a topology and cell-to-cell interactions resembling that of the in vivo tissue. The widespread and increasing adoption of organoid-based technologies in human biomedical research is testament to their enormous potential in basic, translational- and applied-research. In a similar fashion there appear to be ample possibilities for research applications of organoids from livestock and companion animals. Furthermore, organoids as in vitro models offer a great possibility to reduce the use of experimental animals. Here, we provide an overview of studies on organoids in livestock and companion animal species, with focus on the methods developed for organoids from a variety of tissues/organs from various animal species and on the applications in veterinary research. Current limitations, and ongoing research to address these limitations, are discussed. Further, we elaborate on a number of fields of research in animal nutrition, host-microbe interactions, animal breeding and genomics, and animal biotechnology, in which organoids may have great potential as an in vitro research tool.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Organoids: a promising new in vitro platform in livestock and veterinary research

Kar, Soumya K ; Wells, Jerry M ; Ellen, Esther D ; Te Pas, Marinus F W ; Madsen, Ole ; Groenen, Martien A M ; Woelders, Henri

England: BioMed Central Ltd

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