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Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα

Souza, Camila O. ; Teixeira, Alexandre A. S. ; Lima, Edson A. ; Batatinha, Helena A. P. ; Gomes, Lara M. ; Carvalho-Silva, Milena ; Mota, Isabella T. ; Streck, Emilio L. ; Hirabara, Sandro M. ; Neto, José C. Rosa Lira, Fabio S.

Mediators of Inflammation, 2014-01, Vol.2014 (5), p.582197-12 [Periódico revisado por pares]

United States: Hindawi Limiteds

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Título:
Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα
Autor: Souza, Camila O. ; Teixeira, Alexandre A. S. ; Lima, Edson A. ; Batatinha, Helena A. P. ; Gomes, Lara M. ; Carvalho-Silva, Milena ; Mota, Isabella T. ; Streck, Emilio L. ; Hirabara, Sandro M. ; Neto, José C. Rosa
Lira, Fabio S.
Assuntos: Animals ; Blotting, Western ; Diet, High-Fat - adverse effects ; Enzyme-Linked Immunosorbent Assay ; Fatty Acids, Monounsaturated - therapeutic use ; Genetic aspects ; Health aspects ; Insulin Resistance ; Interleukin-12 ; Ketogenic diet ; Liver - drug effects ; Liver - metabolism ; Male ; Metabolic diseases ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Monounsaturated fatty acids ; Oleic Acid - metabolism ; Oleic Acid - therapeutic use ; PPAR alpha - deficiency ; PPAR alpha - genetics ; PPAR alpha - metabolism ; Prevention ; Transcription factors ; Tumor Necrosis Factor-alpha - metabolism
É parte de: Mediators of Inflammation, 2014-01, Vol.2014 (5), p.582197-12
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Fabio S. Lira
Descrição: Palmitoleic acid (PMA) has anti-inflammatory and antidiabetic activities. Here we tested whether these effects of PMA on glucose homeostasis and liver inflammation, in mice fed with high-fat diet (HFD), are PPAR-α dependent. C57BL6 wild-type (WT) and PPAR-α-knockout (KO) mice fed with a standard diet (SD) or HFD for 12 weeks were treated after the 10th week with oleic acid (OLA, 300 mg/kg of b.w.) or PMA 300 mg/kg of b.w. Steatosis induced by HFD was associated with liver inflammation only in the KO mice, as shown by the increased hepatic levels of IL1-beta, IL-12, and TNF-α; however, the HFD increased the expression of TLR4 and decreased the expression of IL1-Ra in both genotypes. Treatment with palmitoleate markedly attenuated the insulin resistance induced by the HFD, increased glucose uptake and incorporation into muscle in vitro, reduced the serum levels of AST in WT mice, decreased the hepatic levels of IL1-beta and IL-12 in KO mice, reduced the expression of TLR-4 and increased the expression of IL-1Ra in WT mice, and reduced the phosphorylation of NF κB (p65) in the livers of KO mice. We conclude that palmitoleate attenuates diet-induced insulin resistance, liver inflammation, and damage through mechanisms that do not depend on PPAR-α.
Editor: United States: Hindawi Limiteds
Idioma: Inglês

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Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα

Souza, Camila O. ; Teixeira, Alexandre A. S. ; Lima, Edson A. ; Batatinha, Helena A. P. ; Gomes, Lara M. ; Carvalho-Silva, Milena ; Mota, Isabella T. ; Streck, Emilio L. ; Hirabara, Sandro M. ; Neto, José C. Rosa Lira, Fabio S.

United States: Hindawi Limiteds

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