Idioma:

Signal Transducer and Activator of Transcription 3 Is Required for Myocardial Capillary Growth, Control of Interstitial Matrix Deposition, and Heart Protection From Ischemic Injury

Hilfiker-Kleiner, Denise ; Hilfiker, Andres ; Fuchs, Martin ; Kaminski, Karol ; Schaefer, Arnd ; Schieffer, Bernhard ; Hillmer, Anja ; Schmiedl, Andreas ; Ding, Zhaoping ; Podewski, Edith ; Podewski, Eva ; Poli, Valeria ; Schneider, Michael D ; Schulz, Rainer ; Park, Joon-Keun ; Wollert, Kai C ; Drexler, Helmut

Circulation research, 2004-07, Vol.95 (2), p.187-195 [Periódico revisado por pares]

Hagerstown, MD: American Heart Association, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Signal Transducer and Activator of Transcription 3 Is Required for Myocardial Capillary Growth, Control of Interstitial Matrix Deposition, and Heart Protection From Ischemic Injury
Autor: Hilfiker-Kleiner, Denise ; Hilfiker, Andres ; Fuchs, Martin ; Kaminski, Karol ; Schaefer, Arnd ; Schieffer, Bernhard ; Hillmer, Anja ; Schmiedl, Andreas ; Ding, Zhaoping ; Podewski, Edith ; Podewski, Eva ; Poli, Valeria ; Schneider, Michael D ; Schulz, Rainer ; Park, Joon-Keun ; Wollert, Kai C ; Drexler, Helmut
Assuntos: Angiogenesis Inhibitors - pharmacology ; Animals ; Biological and medical sciences ; Capillaries - growth & development ; Cardiology. Vascular system ; Cardiomyopathy, Dilated - genetics ; Cell Division - drug effects ; Coronary Vessels - growth & development ; Culture Media, Conditioned - toxicity ; DNA-Binding Proteins - deficiency ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - physiology ; Endothelial Cells - drug effects ; Extracellular Matrix - metabolism ; Fibroblasts - drug effects ; Fibrosis ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Heart ; Heart Failure - etiology ; Heart Failure - prevention & control ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Male ; Medical sciences ; Mice ; Mice, Knockout ; Myocardial Ischemia - complications ; Myocardial Ischemia - genetics ; Myocardial Ischemia - metabolism ; Myocardial Ischemia - prevention & control ; Myocardial Reperfusion Injury - genetics ; Myocardial Reperfusion Injury - metabolism ; Myocardial Reperfusion Injury - prevention & control ; Myocardium - metabolism ; Myocardium - pathology ; Myocytes, Cardiac - metabolism ; Neovascularization, Physiologic - drug effects ; Neovascularization, Physiologic - genetics ; Neovascularization, Physiologic - physiology ; Paracrine Communication ; STAT3 Transcription Factor ; Trans-Activators - deficiency ; Trans-Activators - genetics ; Trans-Activators - physiology ; Vertebrates: cardiovascular system
É parte de: Circulation research, 2004-07, Vol.95 (2), p.187-195
Descrição: The transcription factor signal transducer and activator of transcription 3 (STAT3) participates in a wide variety of physiological processes and directs seemingly contradictory responses such as proliferation and apoptosis. To elucidate its role in the heart, we generated mice harboring a cardiomyocyte-restricted knockout of STAT3 using Cre/loxP–mediated recombination. STAT3-deficient mice developed reduced myocardial capillary density and increased interstitial fibrosis within the first 4 postnatal months, followed by dilated cardiomyopathy with impaired cardiac function and premature death. Conditioned medium from STAT3-deficient cardiomyocytes inhibited endothelial cell proliferation and increased fibroblast proliferation, suggesting the presence of paracrine factors attenuating angiogenesis and promoting fibrosis in vitro. STAT3-deficient mice showed enhanced susceptibility to myocardial ischemia/reperfusion injury and infarction with increased cardiac apoptosis, increased infarct sizes, and reduced cardiac function and survival. Our study establishes a novel role for STAT3 in controlling paracrine circuits in the heart essential for postnatal capillary vasculature maintenance, interstitial matrix deposition balance, and protection from ischemic injury and heart failure.
Editor: Hagerstown, MD: American Heart Association, Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Signal Transducer and Activator of Transcription 3 Is Required for Myocardial Capillary Growth, Control of Interstitial Matrix Deposition, and Heart Protection From Ischemic Injury

Hagerstown, MD: American Heart Association, Inc

Buscando em bases de dados remotas. Favor aguardar.