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Importance of hepatic function on the plasma disappearance and biliary excretion of hexachlorophene

Klaassen, Curtis D.

Toxicology and applied pharmacology, 1979-06, Vol.49 (1), p.113-117 [Periódico revisado por pares]

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Título:
Importance of hepatic function on the plasma disappearance and biliary excretion of hexachlorophene
Autor: Klaassen, Curtis D.
Assuntos: Animals ; Bile - metabolism ; Hexachlorophene - blood ; Hexachlorophene - metabolism ; Hexachlorophene - toxicity ; Liver - metabolism ; Male ; Phenobarbital - pharmacology ; Rats
É parte de: Toxicology and applied pharmacology, 1979-06, Vol.49 (1), p.113-117
Descrição: Hepatic function has been shown to be an important determinant in the removal of hexachlorophene from the body. Within 3 hr after administration, 50% of the drug is excreted into the bile of rats. Pretreatment with phenobarbital enhances the plasma disappearance of hexachlorophene and doubles the rate at which hexachlorophene and its metabolites are excreted into the bile. A decrease in hepatic function produced by two-thirds hepatectomy increased the toxicity of hexachlorophene. Two-thirds hepatectomy also decreased the rate of removal of hexachlorophene from the plasma and decreased its rate of excretion into the bile to about one-third that of control animals. Bile duct ligation also decreased the rate of removal of hexachloraphene from the plasma; however, the accumulation of hexachlorophene-glucuronide in the plasma was more pronounced indicating that if the conjugate cannot be excreted into the bile it enters the plasma.
Editor: United States: Elsevier Inc
Idioma: Inglês

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