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Natural product analogues: towards a blueprint for analogue-focused synthesis

Bebbington, Magnus W. P

Chemical Society reviews, 2017-08, Vol.46 (16), p.559-519 [Periódico revisado por pares]

England

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  • Título:
    Natural product analogues: towards a blueprint for analogue-focused synthesis
  • Autor: Bebbington, Magnus W. P
  • É parte de: Chemical Society reviews, 2017-08, Vol.46 (16), p.559-519
  • Notas: Magnus Bebbington studied Chemistry at the University of Durham, U.K., (MSci, 1999). He moved to the University of Oxford for graduate study with Professor David M. Hodgson (DPhil, 2003). Two postdoctoral appointments followed: from 2003 to 2005 at the Pennsylvania State University, U.S.A. with Professor Steven M. Weinreb and from 2005-2007 a Marie Curie Intraeuropean postdoctoral fellowship with Dr Didier Bourissou at the LHFA, Université Paul Sabatier, Toulouse, France. In October 2007 he moved to Heriot-Watt University, Edinburgh as Assistant Professor/Lecturer in Organic Chemistry. In 2017, he emigrated to the US to join his family.
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  • Descrição: For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed. A review of approaches to natural product analogues leads to the suggestion of new methods for the generation of biologically active natural product-like scaffolds.
  • Editor: England
  • Idioma: Inglês
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