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Polysaccharide from a Tea (Infusion) of Maytenus ilicifolia Leaves with Anti-ulcer Protective Effects

Cipriani, T.R ; Mellinger, C.G ; Souza, L.M. de ; Baggio, C.H ; Freitas, C.S ; Marques, M.C.A ; Gorin, P.A.J ; Sassaki, G.L ; Iacomini, M

Journal of natural products (Washington, D.C.), 2006-07, Vol.69 (7), p.1018-1021 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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Título:
Polysaccharide from a Tea (Infusion) of Maytenus ilicifolia Leaves with Anti-ulcer Protective Effects
Autor: Cipriani, T.R ; Mellinger, C.G ; Souza, L.M. de ; Baggio, C.H ; Freitas, C.S ; Marques, M.C.A ; Gorin, P.A.J ; Sassaki, G.L ; Iacomini, M
Assuntos: anti-ulcer activity ; Anti-Ulcer Agents - chemistry ; Anti-Ulcer Agents - isolation & purification ; Anti-Ulcer Agents - pharmacology ; Beverages ; Biological and medical sciences ; Brazil ; carbohydrate structure ; Celastraceae ; General pharmacology ; Maytenus - chemistry ; Maytenus ilicifolia ; Medical sciences ; medicinal plants ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Leaves - chemistry ; Plants, Medicinal - chemistry ; polysaccharides ; Polysaccharides - chemistry ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; rats ; spectral analysis ; stomach ulcers
É parte de: Journal of natural products (Washington, D.C.), 2006-07, Vol.69 (7), p.1018-1021
Notas: http://dx.doi.org/10.1021/np060045z
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ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Maytenus ilicifolia is a medicinal plant used as a tea (infusion) for treatment of stomach ulcers. This tea furnished a polysaccharide after several purification steps, consisting of a freezing-thawing process, Fehling precipitation, ultrafiltration, and dialysis. It consisted of arabinose, galactose, galacturonic acid, 4-O-methylglucuronic acid, rhamnose, and glucose in a 42:41:6:5:4:2 molar ratio. Methylation analysis, controlled Smith degradation, and NMR spectroscopy indicated that it was a type II arabinogalactan containing a (1-->3)-linked beta-d-Galp main chain, substituted at O-6 by (1-->6)-linked beta-d-Galp chains, which were mainly substituted at O-3 by (1-->5)- and (1-->3)-linked alpha-l-Araf chains, and nonreducing end-units of alpha-l-Araf and 4-O-Me-GlcpA. This polysaccharide significantly inhibited ethanol-induced gastric lesions in rats with an ED(50) of 9.3 mg/kg, suggesting that the arabinogalactan liberated from the infusion has a protective anti-ulcer effect.
Editor: Washington, DC: American Chemical Society
Idioma: Inglês

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Polysaccharide from a Tea (Infusion) of Maytenus ilicifolia Leaves with Anti-ulcer Protective Effects

Cipriani, T.R ; Mellinger, C.G ; Souza, L.M. de ; Baggio, C.H ; Freitas, C.S ; Marques, M.C.A ; Gorin, P.A.J ; Sassaki, G.L ; Iacomini, M

Washington, DC: American Chemical Society

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