Idioma:

Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development

Hu, Jianming ; Lin, You-Yu ; Chen, Pei-Jer ; Watashi, Koichi ; Wakita, Takaji

Gastroenterology (New York, N.Y. 1943), 2019-01, Vol.156 (2), p.338-354 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development
Autor: Hu, Jianming ; Lin, You-Yu ; Chen, Pei-Jer ; Watashi, Koichi ; Wakita, Takaji
Assuntos: Animals ; Cell Culture Techniques ; Cell Line ; Disease Models, Animal ; Drug Development ; Hepatitis B - etiology ; Hepatitis B - therapy ; Hepatitis B virus - physiology ; Humans ; Immune Response ; Models, Immunological ; Mouse ; Treatment ; Viral Infection
É parte de: Gastroenterology (New York, N.Y. 1943), 2019-01, Vol.156 (2), p.338-354
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Many cell culture and animal models have been used to study hepatitis B virus (HBV) replication and its effects in the liver; these have facilitated development of strategies to control and clear chronic HBV infection. We discuss the advantages and limitations of systems for studying HBV and developing antiviral agents, along with recent advances. New and improved model systems are needed. Cell culture systems should be convenient, support efficient HBV infection, and reproduce responses of hepatocytes in the human body. We also need animals that are fully permissive to HBV infection, convenient for study, and recapitulate human immune responses to HBV and effects in the liver. High-throughput screening technologies could facilitate drug development based on findings from cell and animal models.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development

Hu, Jianming ; Lin, You-Yu ; Chen, Pei-Jer ; Watashi, Koichi ; Wakita, Takaji

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.