Idioma:

Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study

Sousa, Angela Maria ; de Santana Neto, José ; Guimaraes, Gabriel M. N. ; Cascudo, Giovana M. ; Neto, José Osvaldo B. ; Ashmawi, Hazem A.

Supportive care in cancer, 2014-03, Vol.22 (3), p.795-801 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

Texto completo disponível

Citações Citado por

Enviar para

Título:
Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study
Autor: Sousa, Angela Maria ; de Santana Neto, José ; Guimaraes, Gabriel M. N. ; Cascudo, Giovana M. ; Neto, José Osvaldo B. ; Ashmawi, Hazem A.
Assuntos: Adult ; Analgesia, Patient-Controlled - adverse effects ; Analgesia, Patient-Controlled - methods ; Analgesics ; Analgesics - adverse effects ; Analgesics - therapeutic use ; Breakthrough Pain - drug therapy ; Breakthrough Pain - etiology ; Cancer ; Cancer patients ; Care and treatment ; Constipation ; Female ; Fentanyl - adverse effects ; Fentanyl - therapeutic use ; Humans ; Intravenous therapy ; Male ; Medical records ; Medicine ; Medicine & Public Health ; Methadone - adverse effects ; Methadone - therapeutic use ; Middle Aged ; Morphine ; Morphine - adverse effects ; Morphine - therapeutic use ; Nausea ; Neoplasms - complications ; Nursing ; Nursing Research ; Oncology ; Oncology, Experimental ; Original Article ; Pain ; Pain management ; Pain Measurement ; Pain Medicine ; Rehabilitation Medicine ; Retrospective Studies ; Side effects
É parte de: Supportive care in cancer, 2014-03, Vol.22 (3), p.795-801
Descrição: Purpose The WHO analgesic ladder supports medication choice according to pain intensity. The use of the analgesic ladder in an inverse way, has the advantage of using the same principles of the original ladder to treat crisis of pain in cancer patients. The purpose of this study is to describe the use of intravenous patient-controlled analgesia (IV-PCA) technique in patients admitted to an oncological Hospital. Methods This is a case series study. Patients assigned to receive IV-PCA between March 2011 and May 2012 were selected for the study. Medical records were reviewed, patients stratified according to the Karnofsky Performance Score (KPS). The primary outcome was to verify if different IV-PCA opioid solutions could be equally effective providing pain relief. Secondary outcomes were the incidence of clinical side effects that can be associated to IV-PCA infusions. Results A total of 95 medical records were reviewed. Most patients used IV-PCA with morphine (42.1 %), fentanyl (42.1 %) or methadone (15.7 %) to treat exacerbation periods of cancer pain. IV-PCA used as supplementary therapy successfully improved pain control in 78.9 % of the patients, without any difference related to opioid solution. KPS <40 was related to higher rate of pain relief, without any difference in side effects in this group of patients. The most common side effects were sedation (10.5 %) followed by constipation (9.4 %) and nausea (4.2 %). Morphine presented a higher risk than fentanyl for sedation. Analgesia-related delirium or respiratory depression were not reported in this case series study. Conclusions IV-PCA provided timely, safe and useful analgesia for patients with severe breakthrough pain and may be useful to help titration of opioids, weaning to oral analgesia and to decide for interventional procedures.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study

Sousa, Angela Maria ; de Santana Neto, José ; Guimaraes, Gabriel M. N. ; Cascudo, Giovana M. ; Neto, José Osvaldo B. ; Ashmawi, Hazem A.

Berlin/Heidelberg: Springer Berlin Heidelberg

Buscando em bases de dados remotas. Favor aguardar.