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Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells

Turville, Stuart G. ; Santos, John J. ; Frank, Ines ; Cameron, Paul U. ; Wilkinson, John ; Miranda-Saksena, Monica ; Dable, Joanne ; Stössel, Hella ; Romani, Nikolaus ; Piatak, Michael ; Lifson, Jeffrey D. ; Pope, Melissa ; Cunningham, Anthony L.

Blood, 2004-03, Vol.103 (6), p.2170-2179 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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Título:
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells
Autor: Turville, Stuart G. ; Santos, John J. ; Frank, Ines ; Cameron, Paul U. ; Wilkinson, John ; Miranda-Saksena, Monica ; Dable, Joanne ; Stössel, Hella ; Romani, Nikolaus ; Piatak, Michael ; Lifson, Jeffrey D. ; Pope, Melissa ; Cunningham, Anthony L.
Assuntos: 2,2'-Dipyridyl - analogs & derivatives ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - virology ; Cells, Cultured ; Dendritic Cells - immunology ; Dendritic Cells - ultrastructure ; Dendritic Cells - virology ; Disulfides ; HIV Envelope Protein gp120 - metabolism ; HIV Infections - immunology ; HIV-1 - growth & development ; HIV-1 - immunology ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Microscopy, Electron ; Protein Binding ; Protein Transport ; Simian Immunodeficiency Virus - immunology ; Sulfhydryl Reagents ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids
É parte de: Blood, 2004-03, Vol.103 (6), p.2170-2179
Descrição: HIV-1 subverts antigen processing in dendritic cells (DCs) resulting in viral uptake, infection, and transfer to T cells. Although DCs bound monomeric gp120 and HIV-1 similarly, virus rarely colocalized with endolysosomal markers, unlike gp120, suggesting HIV-1 alters endolysosomal trafficking. Virus within DC intracellular compartments rapidly moved to DC-CD4+ lymphocyte synapses when introduced to CD4+ lymphocyte cultures. Although viral harboring and transfer from nonlysosomal compartments was transient, given DC-associated virus protein, nucleic acids, and infectious HIV-1 transfer to CD4+, lymphocytes decayed within 24 hours. However a second long-term transfer phase was apparent in immature DCs after 48 hours as a zidovudine-sensitive rise in proviral DNA. Therefore, DCs transfer HIV-1 to CD4+ lymphocytes in 2 distinct phases. Immature and mature DCs first divert virus from the endolysosomal pathway to the DC–T-cell synapse. Secondly, the later transfer phase from immature DCs is through de novo HIV-1 production. Thus, the controversy of DCs being infected or not infected for the mechanics of viral transfer to CD4+ lymphocytes can be addressed as a function of time.
Editor: Washington, DC: Elsevier Inc
Idioma: Inglês

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Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells

Turville, Stuart G. ; Santos, John J. ; Frank, Ines ; Cameron, Paul U. ; Wilkinson, John ; Miranda-Saksena, Monica ; Dable, Joanne ; Stössel, Hella ; Romani, Nikolaus ; Piatak, Michael ; Lifson, Jeffrey D. ; Pope, Melissa ; Cunningham, Anthony L.

Washington, DC: Elsevier Inc

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