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Within-Host and Population Transmission of bla.sub.OXA-48 in K. pneumoniae and E. coli

Haverkate, Manon R ; Dautzenberg, Mirjam J. D ; Ossewaarde, Tjaco J. M ; van der Zee, Anneke ; den Hollander, Jan G ; Troelstra, Annet ; Bonten, Marc J. M ; Bootsma, Martin C. J

PloS one, 2015-10, Vol.10 (10) [Periódico revisado por pares]

Public Library of Science

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  • Título:
    Within-Host and Population Transmission of bla.sub.OXA-48 in K. pneumoniae and E. coli
  • Autor: Haverkate, Manon R ; Dautzenberg, Mirjam J. D ; Ossewaarde, Tjaco J. M ; van der Zee, Anneke ; den Hollander, Jan G ; Troelstra, Annet ; Bonten, Marc J. M ; Bootsma, Martin C. J
  • Assuntos: Antibiotics ; Bacterial pneumonia ; Care and treatment ; Diagnosis ; Dosage and administration ; Escherichia coli ; Physiological aspects ; Pneumonia ; Risk factors
  • É parte de: PloS one, 2015-10, Vol.10 (10)
  • Descrição: During a large hospital outbreak of OXA-48 producing bacteria, most K. pneumoniae.sub.OXA-48 isolates were phenotypically resistant to meropenem or imipenem, whereas most E. coli.sub.OXA-48 isolates were phenotypically susceptible to these antibiotics. In the absence of molecular gene-detection E. coli.sub.OXA-48 could remain undetected, facilitating cross-transmission and horizontal gene transfer of bla.sub.OXA-48 . Based on 868 longitudinal molecular microbiological screening results from patients carrying K. pneumoniae.sub.OXA-48 (n = 24), E. coli.sub.OXA-48 (n = 17), or both (n = 40) and mathematical modelling we determined mean durations of colonisation (278 and 225 days for K. pneumoniae.sub.OXA-48 and E. coli.sub.OXA-48, respectively), and horizontal gene transfer rates (0.0091/day from K. pneumoniae to E. coli and 0.0015/day vice versa). Based on these findings the maximum effect of horizontal gene transfer of bla.sub.OXA-48 originating from E. coli.sub.OXA-48 on the basic reproduction number (R.sub.0) is 1.9%, and it is, therefore, unlikely that phenotypically susceptible E. coli.sub.OXA-48 will contribute significantly to the spread of bla.sub.OXA-48.
  • Editor: Public Library of Science
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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