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Assessing the risk of coal-burning arsenic-induced liver damage: a population-based study on hair arsenic and cumulative arsenic

Yao, Maolin ; Zeng, Qibing ; Luo, Peng ; Sun, Baofei ; Liang, Bing ; Wei, Shaofeng ; Xu, Yuyan ; Wang, Qingling ; Liu, Qizhan ; Zhang, Aihua

Environmental science and pollution research international, 2021-09, Vol.28 (36), p.50489-50499 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Assessing the risk of coal-burning arsenic-induced liver damage: a population-based study on hair arsenic and cumulative arsenic
Autor: Yao, Maolin ; Zeng, Qibing ; Luo, Peng ; Sun, Baofei ; Liang, Bing ; Wei, Shaofeng ; Xu, Yuyan ; Wang, Qingling ; Liu, Qizhan ; Zhang, Aihua
Assuntos: Aquatic Pollution ; Arsenic ; Arsenic - analysis ; Arsenic Poisoning - epidemiology ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bayes Theorem ; Bayesian analysis ; Burning ; China - epidemiology ; Coal ; Damage ; Drinking water ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Exposure ; Environmental Health ; Exposure ; Food additives ; Food contamination ; Hair ; Humans ; Indoor environments ; Ingestion ; Inhalation ; Liver ; Liver - chemistry ; Organs ; Peppers ; Population studies ; Public health ; Research Article ; Respiration ; Risk assessment ; Stoves ; Waste Water Technology ; Water Management ; Water Pollution Control
É parte de: Environmental science and pollution research international, 2021-09, Vol.28 (36), p.50489-50499
Descrição: Exposure to arsenic-contaminated air and food caused by the burning of coal in unventilated indoor stoves is a major environmental public health concern in Guizhou Province, China. The liver is one of the main target organs for coal-fired arsenic exposure; however, there is little information about the risk assessment between cumulative arsenic exposure and the prevalence of liver damage. This study first evaluated the chronic daily intake (CDI) for two exposure pathways (inhalation and ingestion) and five environmental media (i.e., indoor and outdoor air, drinking water, rice, corn, and chili peppers) in 1998, 2006, 2014, and 2017. Then, the dose-effect and dose-response relationship between hair arsenic (HA) and cumulative arsenic (CA) levels and liver damage was analyzed. The results clearly show that the CDI in 1998 was 34.9 μg·kg −1 ·d −1 , 22.9 μg·kg −1 ·d −1 in 2006, 11.7 μg·kg −1 ·d −1 in 2014, and 6.7 μg·kg −1 ·d −1 in 2017 in the arsenic exposure area. All of these values were higher than the daily baseline level of 3.0 μg·kg −1 ·d −1 as recommended by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and the increased HA and CA can increase the risk of coal-fired arsenic-induced liver damage. In addition, we analyzed the possible maximum acceptable CA exposure level for coal-fired arsenic-induced liver damage using the Bayesian benchmark dose. The recommended maximum acceptable CA exposure level for liver damage caused by coal-burning arsenic is 7120 mg. This study provides scientific insight into understanding the dose-response relationship of liver damage caused by coal-burning arsenic exposure and the monitoring and prevention of arsenic poisoning.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Assessing the risk of coal-burning arsenic-induced liver damage: a population-based study on hair arsenic and cumulative arsenic

Yao, Maolin ; Zeng, Qibing ; Luo, Peng ; Sun, Baofei ; Liang, Bing ; Wei, Shaofeng ; Xu, Yuyan ; Wang, Qingling ; Liu, Qizhan ; Zhang, Aihua

Berlin/Heidelberg: Springer Berlin Heidelberg

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