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Perilla frutescens: A new strategy for uranium decorporation

Cao, Yalan ; Wang, Zeru ; Song, Wanrong ; Liu, Yawen ; Zhao, Qian ; Li, Wenhao ; Zheng, Caohui ; Li, Wenshuang ; Chen, Zhengguo ; Zhu, Lin ; Duan, Tao ; Li, Xiaoan

Chemosphere (Oxford), 2024-02, Vol.350, p.141066-141066, Article 141066 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Perilla frutescens: A new strategy for uranium decorporation
  • Autor: Cao, Yalan ; Wang, Zeru ; Song, Wanrong ; Liu, Yawen ; Zhao, Qian ; Li, Wenhao ; Zheng, Caohui ; Li, Wenshuang ; Chen, Zhengguo ; Zhu, Lin ; Duan, Tao ; Li, Xiaoan
  • Assuntos: Biocompatibility ; Biological Products - pharmacology ; Chelating Agents - pharmacology ; Decorporation ; Humans ; Kidney ; Natural product ; Perilla frutescens ; Uranium - toxicity ; Uranyl
  • É parte de: Chemosphere (Oxford), 2024-02, Vol.350, p.141066-141066, Article 141066
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Radionuclide uranium is a great threat to human health, due to its high chemical toxicity and radioactivity. Finding suitable uranium decorporation to reduce damage caused by uranium internal contamination is an important aspect of nuclear emergency response. However, the poor selectivity and/or high toxicity of the only excretory promoter approved by Food and Drug Administration (FDA) is an obvious disadvantage. Herein, we choose an edible natural product, the traditional Chinese medicine called Perilla frutescens (PF), which has wide sources and can be used as an excellent and effective uranyl decorporation. In vivo uranium decorporation assays illustrate the removal efficiency of uranium in kidney were 68.87% and 43.26%, in femur were 56.66% and 54.53%, by the test of prophylactic and immediate administration, respectively. Cell level experiments confirmed that it had better biocompatibility than CaNa3-DTPA (CaNa3-diethylenetriamine pentaacetate, a commercial actinide excretion agent). In vitro static adsorption experiments exhibited that its excellent selectivity sorption for uranyl. All those results findings would provide new research insights about natural product for uranyl decorporation. [Display omitted] •Perilla frutescens (PF) have better excellent biocompatibility than CaNa3-DTPA.•PF has high selectivity for uranium and does not capture trace elements.•PF significantly promotes the release of U(VI) from cells.•PF can effectively remove uranium deposited in kidney (>65%) and bone (>55%) of mice.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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