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Resveratrol: A multitargeted agent for age-associated chronic diseases

Harikumar, Kuzhuvelil B. ; Aggarwal, Bharat B.

Cell cycle (Georgetown, Tex.), 2008-04, Vol.7 (8), p.1020-1035 [Periódico revisado por pares]

United States: Taylor & Francis

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  • Título:
    Resveratrol: A multitargeted agent for age-associated chronic diseases
  • Autor: Harikumar, Kuzhuvelil B. ; Aggarwal, Bharat B.
  • Assuntos: Aging - drug effects ; Binding ; Biology ; Bioscience ; Calcium ; Cancer ; Cardiotonic Agents ; Cell ; Cycle ; Gene Expression Regulation - physiology ; Gene Regulatory Networks - physiology ; Inflammation - drug therapy ; Intracellular Signaling Peptides and Proteins - metabolism ; Landes ; Neoplasms - drug therapy ; Organogenesis ; Platelet Aggregation - drug effects ; Proteins ; Stilbenes - chemistry ; Stilbenes - metabolism ; Stilbenes - pharmacokinetics ; Stilbenes - pharmacology ; Stilbenes - therapeutic use ; Transcription Factors - metabolism
  • É parte de: Cell cycle (Georgetown, Tex.), 2008-04, Vol.7 (8), p.1020-1035
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Extensive research within the last decade has revealed that most chronic illnesses such as cancer, cardiovascular and pulmonary diseases, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. Thus mono-targeted therapies developed for the last two decades for these diseases have proven to be unsafe, ineffective and expensive. Although fruits and vegetables are regarded to have therapeutic potential against chronic illnesses, neither their active component nor the mechanism of action is well understood. Resveratrol (trans-3, 5, 4'-trihydroxystilbene), a component of grapes, berries, peanuts and other traditional medicines, is one such polyphenol that has been shown to mediate its effects through modulation of many different pathways. This stilbene has been shown to bind to numerous cell-signaling molecules such as multi drug resistance protein, topoisomerase II, aromatase, DNA polymerase, estrogen receptors, tubulin and F1-ATPase. Resveratrol has also been shown to activate various transcription factor (e.g; NF-κB, STAT3, HIF-1α, β-catenin and PPAR-γ), suppress the expression of antiapoptotic gene products (e.g; Bcl-2, Bcl-XL, XIAP and survivin), inhibit protein kinases (e.g; src, PI3K, JNK, and AKT), induce antioxidant enzymes (e,g; catalase, superoxide dismutase and hemoxygenase-1), suppress the expression of inflammatory biomrkers (e.g; TNF, COX-2, iNOS, and CRP), inhibit the expression of angiogenic and metstatic gene products (e.g; MMPs, VEGF, cathepsin D, and ICAM-1), and modulate cell cycle regulatory genes (e.g; p53, Rb, PTEN, cyclins and CDKs). Numerous animal studies have demonstrated that this polyphenol holds promise against numerous age-associated diseases including cancer, diabetes, Alzheimer, cardiovascular and pulmonary diseases. In view of these studies, resveratrol's prospects for use in the clinics are rapidly accelerating. Efforts are also underway to improve its activity in vivo through structural modification and reformulation. Ours review describes various targets of resveratrol and their therapeutic potential.
  • Editor: United States: Taylor & Francis
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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